Ocampo-Torres Mario Cesar, Bravo-Rojas Francisco Martin, Martínez-Badajoz Aida, Hernández-Vásquez Ramiro, Ramírez-Pérez Astrid Asminda, Camargo-Coronel Adolfo, Vázquez-Zaragoza Miguel Ángel, Luna-Peña Eleonor, Pazos-Pérez Fabiola, Hernández-Rivera Juan Carlos H
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Reumatología. Ciudad de México, México.
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Unidad de Investigación Médica en Enfermedades Nefrológicas. Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2024 Jan 8;62(1):1-6. doi: 10.5281/zenodo.10278103.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs and body systems.
To describe the sociodemographic, clinical, and biochemical characteristics of the Lupus-IMMS-Mexico (LUPUS-IMMex) patient cohort from a tertiary-level center.
Observational descriptive study of 160 patients with diagnosis of SLE belonging to the aforementioned cohort. Various variables were analyzed at the time of diagnosis. For quantitative variables, normality tests were applied, followed by measures of central tendency and dispersion according to their distribution. For categorical variables, frequencies and percentages were calculated.
81.87% of the patients were female, with a median age at diagnosis of 28 years. 18.12% had a family history of SLE, and concurrently with SLE, 32.50% had hypertension, and 11.25% had antiphospholipid syndrome. The most common clinical manifestation was joint involvement (68.12%), renal (49.37%) and hematological (43.75%) manifestations.
SLE affects millions globally. Lack of awareness leads to delayed diagnoses, suboptimal management, and diminished quality of life. After analyzing 160 patients with SLE, their clinical, socioeconomic, and therapeutic characteristics are largely like other cohorts, with differences attributable to ethnic and geographical influences. Informing patients about SLE and providing reliable resources are essential for self-care. Awareness promotes research, therapies, and enhances medical care and the lives of patients globally.
系统性红斑狼疮（SLE）是一种可影响多个器官和身体系统的慢性自身免疫性疾病。
描述来自三级中心的墨西哥狼疮免疫队列研究（Lupus-IMMS-Mexico，LUPUS-IMMex）患者群体的社会人口学、临床和生化特征。
对上述队列中160例诊断为SLE的患者进行观察性描述性研究。在诊断时分析了各种变量。对于定量变量，应用正态性检验，然后根据其分布进行集中趋势和离散度测量。对于分类变量，计算频率和百分比。
81.87%的患者为女性，诊断时的中位年龄为28岁。18.12%有SLE家族史，同时患有SLE的患者中，32.50%患有高血压，11.25%患有抗磷脂综合征。最常见的临床表现是关节受累（68.12%）、肾脏受累（49.37%）和血液系统受累（43.75%）。
SLE在全球影响数百万人。缺乏认识导致诊断延迟、治疗欠佳和生活质量下降。在分析了160例SLE患者后，他们的临床、社会经济和治疗特征在很大程度上与其他队列相似，差异归因于种族和地理影响。告知患者有关SLE的信息并提供可靠的资源对自我护理至关重要。提高认识可促进研究、治疗，并改善全球患者的医疗护理和生活。
