State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, China; Department of Orthodontics, School and Hospital of Stomatology, Jilin University, China.
College of Basic Medical Sciences, Jilin University, China.
Dent Mater. 2024 Nov;40(11):1710-1728. doi: 10.1016/j.dental.2024.07.025. Epub 2024 Aug 5.
Nanozyme materials combine the advantages of natural enzymes and artificial catalysis, and have been widely applied in new technologies for dental materials and oral disease treatment. Based on the role of reactive oxygen species (ROS) and oxidative stress pathways in the occurrence and therapy of oral diseases, a comprehensive review was conducted on the methods and mechanisms of nanozymes and their dental materials in treating different oral diseases.
This review is based on literature surveys from PubMed and Web of Science databases, as well as reviews of relevant researches and publications on nanozymes in the therapy of oral diseases and oral tumors in international peer-reviewed journals.
Given the unique function of nanozymes in the generation and elimination of ROS, they play an important role in the occurrence, development, and treatment of different oral diseases. The application of nanozymes in dental materials and oral disease treatment was introduced, including the latest advances in their use for dental caries, pulpitis, jaw osteomyelitis, periodontitis, oral mucosal diseases, temporomandibular joint disorders, and oral tumors. Future approaches were also summarized and proposed based on the characteristics of these diseases.
This review will guide biomedical researchers and oral clinicians to understand the mechanisms and applications of nanozymes in the therapy of oral diseases, promoting further development in the field of dental materials within the oral medication. It is anticipated that more suitable therapeutic agents or dental materials encapsulating nanozymes, specifically designed for the oral environment and simpler for clinical utilization, will emerge in the forthcoming future.
纳米酶材料结合了天然酶和人工催化的优点，已广泛应用于牙科材料和口腔疾病治疗的新技术中。基于活性氧（ROS）和氧化应激途径在口腔疾病发生和治疗中的作用，对纳米酶及其在治疗不同口腔疾病中的牙科材料的方法和机制进行了全面综述。
本综述基于 PubMed 和 Web of Science 数据库的文献调查，以及对国际同行评议期刊中关于纳米酶在口腔疾病和口腔肿瘤治疗中的相关研究和出版物的综述。
鉴于纳米酶在 ROS 的产生和消除方面的独特功能，它们在不同口腔疾病的发生、发展和治疗中起着重要作用。介绍了纳米酶在牙科材料和口腔疾病治疗中的应用，包括其在龋齿、牙髓炎、颌骨骨髓炎、牙周炎、口腔黏膜疾病、颞下颌关节紊乱和口腔肿瘤治疗中的最新进展。还根据这些疾病的特点总结并提出了未来的方法。
本综述将指导生物医学研究人员和口腔临床医生了解纳米酶在口腔疾病治疗中的机制和应用，促进口腔药物领域牙科材料的进一步发展。预计未来会出现更适合口腔环境、更便于临床应用的、专门针对口腔疾病的、封装有纳米酶的治疗剂或牙科材料。
