Bu Jin-Wei, Wang Zhi-Gang, Liu Hao-Yang, Liu Shu-Lin
Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R. China.
College of Chemistry and School of Medicine, Nankai University, Tianjin 300071, P. R. China.
Int J Pharm. 2024 Sep 5;662:124453. doi: 10.1016/j.ijpharm.2024.124453. Epub 2024 Jul 14.
Nanozymes, nanostructured materials emulating natural enzyme activities, exhibit potential in catalyzing reactive oxygen species (ROS) production for cancer treatment. By facilitating oxidative reactions, elevating ROS levels, and influencing the tumor microenvironment (TME), nanozymes foster the eradication of cancer cells. Noteworthy are their superior stability, ease of preservation, and cost-effectiveness compared to natural enzymes, rendering them invaluable for medical applications. This comprehensive review intricately explores the interplay between ROS and tumor therapy, with a focused examination of metal-based nanozyme strategies mitigating tumor hypoxia. It provides nuanced insights into diverse catalytic processes, mechanisms, and surface modifications of various metal nanozymes, shedding light on their role in intra-tumoral ROS generation and applications in antioxidant therapy. The review concludes by delineating specific potential prospects and challenges associated with the burgeoning use of metal nanozymes in future tumor therapies.
纳米酶是模拟天然酶活性的纳米结构材料，在催化产生活性氧（ROS）用于癌症治疗方面具有潜力。通过促进氧化反应、提高ROS水平和影响肿瘤微环境（TME），纳米酶有助于消除癌细胞。与天然酶相比，它们具有卓越的稳定性、易于保存和成本效益，这使其在医学应用中具有不可估量的价值。这篇综述深入探讨了ROS与肿瘤治疗之间的相互作用，重点研究了减轻肿瘤缺氧的金属基纳米酶策略。它对各种金属纳米酶的不同催化过程、机制和表面修饰提供了细致入微的见解，阐明了它们在肿瘤内ROS生成中的作用以及在抗氧化治疗中的应用。综述最后阐述了与金属纳米酶在未来肿瘤治疗中的新兴应用相关的具体潜在前景和挑战。
