Department of Neuroscience, University of California, Berkeley, California, USA.
Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Alzheimers Dement. 2024 Oct;20(10):7340-7349. doi: 10.1002/alz.14165. Epub 2024 Aug 6.
The Alzheimer's Disease Neuroimaging Initiative (ADNI) PET Core has evolved over time, beginning with positron emission tomography (PET) imaging of a subsample of participants with [F]fluorodeoxyglucose (FDG)-PET, adding tracers for measurement of β-amyloid, followed by tau tracers. This review examines the evolution of the ADNI PET Core, the novel aspects of PET imaging in each stage of ADNI, and gives an accounting of PET images available in the ADNI database. The ADNI PET Core has been and continues to be a rich resource that provides quantitative PET data and preprocessed PET images to the scientific community, allowing interrogation of both basic and clinically relevant questions. By standardizing methods across different PET scanners and multiple PET tracers, the Core has demonstrated the feasibility of large-scale, multi-center PET studies. Data managed and disseminated by the PET Core has been critical to defining pathophysiological models of Alzheimer's disease (AD) and helped to drive methods used in modern therapeutic trials. HIGHLIGHTS: The ADNI PET Core began with FDG-PET and now includes three amyloid and three tau PET ligands. The PET Core has standardized acquisition and analysis of multitracer PET images. The ADNI PET Core helped to develop methods that have facilitated clinical trials in AD.
阿尔茨海默病神经影像学倡议（ADNI）正电子发射断层扫描（PET）核心随着时间的推移而不断发展，最初是对 [F]氟脱氧葡萄糖（FDG）-PET 的一部分参与者进行正电子发射断层扫描（PET）成像，随后添加了β-淀粉样蛋白测量示踪剂，然后是tau 示踪剂。本综述检查了 ADNI PET 核心的演变、ADNI 每个阶段的 PET 成像的新方面，并介绍了 ADNI 数据库中可用的 PET 图像。ADNI PET 核心一直是并且仍然是一个丰富的资源，为科学界提供定量 PET 数据和预处理的 PET 图像，允许对基础和临床相关问题进行询问。通过在不同的 PET 扫描仪和多个 PET 示踪剂之间标准化方法，该核心证明了大规模、多中心 PET 研究的可行性。由 PET 核心管理和传播的数据对于定义阿尔茨海默病（AD）的病理生理模型至关重要，并有助于推动现代治疗试验中使用的方法。 要点： ADNI PET 核心最初使用 FDG-PET，现在包括三种淀粉样蛋白和三种 tau PET 配体。 PET 核心已经标准化了多示踪剂 PET 图像的采集和分析。 ADNI PET 核心有助于开发促进 AD 临床试验的方法。
