CenTauR：迈向用于标准化tau成像研究的通用量表和掩膜。

CenTauR: Toward a universal scale and masks for standardizing tau imaging studies.

作者信息

Villemagne Victor L, Leuzy Antoine, Bohorquez Sandra Sanabria, Bullich Santiago, Shimada Hitoshi, Rowe Christopher C, Bourgeat Pierrick, Lopresti Brian, Huang Kun, Krishnadas Natasha, Fripp Jurgen, Takado Yuhei, Gogola Alexandra, Minhas Davneet, Weimer Robby, Higuchi Makoto, Stephens Andrew, Hansson Oskar, Doré Vincent

机构信息

Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.

Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia.

出版信息

Alzheimers Dement (Amst). 2023 Jul 7;15(3):e12454. doi: 10.1002/dad2.12454. eCollection 2023 Jul-Sep.

INTRODUCTION

Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale.

METHOD

One thousand forty-five participants underwent tau scans with either F-flortaucipir, F-MK6240, F-PI2620, F-PM-PBB3, F-GTP1, or F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)- subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR, was constructed.

RESULTS

None of the regions known to display off-target signal were included in the masks. The CenTauR allows robust discrimination between low and high levels of tau deposits.

DISCUSSION

We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.

引言

最近，越来越多的tau示踪剂可供使用。需要对不同示踪剂的定量tau测量进行标准化，以支持通用量表。我们开发了几种皮质tau掩码，并将其应用于生成tau成像通用量表。

方法

1045名参与者接受了使用F-flortaucipir、F-MK6240、F-PI2620、F-PM-PBB3、F-GTP1或F-RO948进行的tau扫描。通用掩码由认知功能未受损的淀粉样β蛋白（Aβ）阴性受试者和Aβ阳性的阿尔茨海默病（AD）患者生成。在通用掩码的限制范围内定义了另外四个区域皮质掩码。构建了一个通用量表CenTauR。