Deng Sisi, Huang Xuezhu, Lei Xiaofeng
Department of Anesthesiology, Women and Children's Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), Chongqing, China.
Heliyon. 2024 Jul 11;10(14):e34161. doi: 10.1016/j.heliyon.2024.e34161. eCollection 2024 Jul 30.
Daytime hysteroscopy requires anesthesia that offers rapid onset and clearance, with minimal respiratory and cardiovascular suppression. This study compared the effects of different doses of alfentanil combined with propofol target-controlled infusion (TCI) for such procedures.
We randomized 240 patients undergoing daytime hysteroscopy into three groups to receive alfentanil at doses of 5 μg/kg, 10 μg/kg, and 15 μg/kg, combined with propofol TCI. We meticulously recorded complications and perioperative vitals to evaluate the safety and efficacy of each dosage regimen.
The 10 μg/kg dose of alfentanil, used in conjunction with propofol, required lower propofol dosages and resulted in quicker recovery time and fewer intraoperative movements. However, higher doses of 15 μg/kg led to a significant increase in hypoxemia and instability in hemodynamics and oxygenation.
Combining alfentanil at 10 μg/kg with propofol TCI for daytime hysteroscopy results in high effectiveness. A lower incidence of complications, a reduced propofol requirement, and rapid emergence from sedation characterize this regimen.
日间宫腔镜检查需要起效迅速且清除快、对呼吸和心血管抑制最小的麻醉。本研究比较了不同剂量阿芬太尼联合丙泊酚靶控输注（TCI）用于此类手术的效果。
我们将240例行日间宫腔镜检查的患者随机分为三组，分别接受5μg/kg、10μg/kg和15μg/kg剂量的阿芬太尼联合丙泊酚TCI。我们仔细记录并发症及围手术期生命体征，以评估每种给药方案的安全性和有效性。
10μg/kg剂量的阿芬太尼与丙泊酚联合使用时，所需丙泊酚剂量更低，恢复时间更快，术中活动更少。然而，15μg/kg的高剂量导致低氧血症显著增加，血流动力学和氧合不稳定。
10μg/kg阿芬太尼与丙泊酚TCI联合用于日间宫腔镜检查效果良好。该方案并发症发生率较低，丙泊酚需求量减少，镇静后苏醒迅速。
