Department of Dermatology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd PCAM South Tower, 7th Floor , Philadelphia, PA 19104, USA.
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Arch Dermatol Res. 2024 Aug 7;316(8):506. doi: 10.1007/s00403-024-03247-y.
The two most prevalent childhood vascular abnormalities are infantile hemangioma (IH) and port-wine stain (PWS). They become apparent shortly after birth but have distinct pathophysiology and clinical manifestations. The goal of this study was to determine if mother's history of angioma or PWS is associated with these vascular abnormalities. We evaluated an UK anonymized electronic medical records database with medical records that were linked between children and their mothers. Cox proportional hazards models were used to evaluate the association between maternal factors and the time of onset of either IH or PWS in children. Between 2004 and 2021, 639,085 children were linked to their mom's medical data with a total of 4,270,773 person-years of follow up. Children born to mothers with an angioma as compared to a mother without an angioma were more than 60% more likely to have an IH (HR: 1.64 [1.07, 2.52]). Children born to mothers with a PWS as compared to children born to mothers without a PWS were nearly 20 times more likely to have a PWS (18.95 [4.71,76.26]). Mothers with angiomas were not more likely to have children with PWS and mothers with PWS were not more likely to have children with IH. The effect estimates were minimally changed after adjustment. We demonstrated that children born to mothers with angiomas or PWS were at increased risk of IH or PWS, respectively.
两种最常见的儿童血管异常是婴儿血管瘤（IH）和葡萄酒色斑（PWS）。它们在出生后不久就会显现出来，但具有不同的病理生理学和临床表现。本研究的目的是确定母亲是否有血管瘤或葡萄酒色斑史与这些血管异常有关。我们评估了一个英国匿名电子病历数据库，该数据库将儿童与其母亲的病历进行了关联。使用 Cox 比例风险模型来评估母亲因素与儿童 IH 或 PWS 发病时间之间的关联。在 2004 年至 2021 年期间，有 639,085 名儿童与其母亲的医疗数据相关联，总共有 4,270,773 人年的随访时间。与没有血管瘤的母亲相比，患有血管瘤的母亲所生的孩子患 IH 的可能性要高出 60%以上（HR：1.64 [1.07, 2.52]）。与没有葡萄酒色斑的母亲相比，患有葡萄酒色斑的母亲所生的孩子患葡萄酒色斑的可能性要高出近 20 倍（18.95 [4.71,76.26]）。患有血管瘤的母亲不太可能有患有葡萄酒色斑的孩子，而患有葡萄酒色斑的母亲不太可能有患有 IH 的孩子。调整后，估计值的变化很小。我们证明，患有血管瘤或葡萄酒色斑的母亲所生的孩子患 IH 或 PWS 的风险分别增加。
