Schoch Jennifer J, Hunjan Manrup K, Anderson Katelyn R, Lohse Christine M, Hand Jennifer L, Davis Dawn M R, Tollefson Megha M
Department of Dermatology, University of Florida, Gainesville, Florida, USA.
Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Pediatr Dermatol. 2018 Nov;35(6):787-791. doi: 10.1111/pde.13659. Epub 2018 Sep 6.
BACKGROUND/OBJECTIVES: Specific maternal risk factors have recently been identified in the development of infantile hemangiomas (IH), including gestational diabetes (GDM), maternal antihypertensive medication use or gestational hypertension (GHTN), maternal progesterone use, and artificial reproductive technologies (ART). We sought to explore the change in incidence of these risk factors over time and determine their association with the increased incidence of hemangiomas over 35 years, as previously reported.
The charts of 869 mother and infant pairs (infants previously diagnosed with IH between January 1, 1976, and December 31, 2010) were reviewed for prenatal complications. Rates of the prenatal complications over the 35-year period in birth mothers of infants diagnosed with IH were determined and evaluated by year of diagnosis (1976-1990, 1991-2000, and 2001-2010).
Over the 35-year period in which the incidence of IH was previously examined, maternal age at delivery, prepregnancy body mass index (BMI), use of ART, maternal progesterone use, placental abnormalities, and GDM also increased.
GDM, ART, and maternal progesterone use increased over the past 35 years, mirroring the previously reported trend of increasing incidence of IH. Maternal age and BMI also increased in mothers of infants with IH. Further exploration of this association may direct future research in the pathogenesis of infantile hemangiomas.
背景/目的：最近已确定婴儿血管瘤（IH）发生发展中的特定母体风险因素，包括妊娠期糖尿病（GDM）、母体使用抗高血压药物或妊娠期高血压（GHTN）、母体使用孕酮以及辅助生殖技术（ART）。正如之前报道的那样，我们试图探讨这些风险因素的发生率随时间的变化，并确定它们与35年来血管瘤发病率增加之间的关联。
回顾了869对母婴的病历（婴儿在1976年1月1日至2010年12月31日期间曾被诊断为IH），以了解产前并发症情况。确定并按诊断年份（1976 - 1990年、1991 - 2000年和2001 - 2010年）评估诊断为IH的婴儿的生母在35年期间的产前并发症发生率。
在之前研究过的35年期间，IH发病率上升的同时，产妇分娩年龄、孕前体重指数（BMI）、辅助生殖技术的使用、母体孕酮的使用、胎盘异常以及妊娠期糖尿病也有所增加。
在过去35年中，妊娠期糖尿病、辅助生殖技术和母体孕酮的使用有所增加，这与之前报道的婴儿血管瘤发病率上升趋势一致。患有血管瘤婴儿的母亲的年龄和BMI也有所增加。对这种关联的进一步探索可能会为婴儿血管瘤发病机制的未来研究指明方向。
