Charton M, Panis G, Brisset J M, Veillon B, Vallancien G, Selles J P
Pathol Biol (Paris). 1985 Jun;33(5 Pt 2):530-2.
20, 30 and 90 minutes after a single intravenous injection of 2 g of cefotiam prostatic tissue and serum samples were taken from 12 patients who underwent transabdominal prostatectomy for prostatic adenoma. Cefotiam was assayed by HPLC. Mean serum and prostatic concentrations were respectively 157 +/- 39 mg/ml and 42 +/- 23 mg/g at 20 mn, 77 +/- 52 mg/ml and 54 +/- 2 mg/g at 30 mn, 36 +/- 21 mg/ml and 16 +/- 18 mg/g at 90 mn. Elimination half-life of cefotiam was 1 h 39 mn for serum and 1 h 10 mn for prostatic tissue. These findings confirm the satisfactory diffusion of cefotiam within prostatic tissue, although saturation occurs after 30 mn. Treatment of prostatitis by cefotiam can be expected to give excellent results.
在12例因前列腺腺瘤接受经腹前列腺切除术的患者单次静脉注射2克头孢替安后20、30和90分钟，采集前列腺组织和血清样本。采用高效液相色谱法测定头孢替安。20分钟时血清和前列腺平均浓度分别为157±39毫克/毫升和42±23毫克/克，30分钟时为77±52毫克/毫升和54±2毫克/克，90分钟时为36±21毫克/毫升和16±18毫克/克。头孢替安在血清中的消除半衰期为1小时39分钟，在前列腺组织中为1小时10分钟。这些发现证实了头孢替安在前列腺组织内的扩散令人满意，尽管30分钟后会出现饱和。预计头孢替安治疗前列腺炎会取得优异效果。
