Mandin Pierre, Gottesman Susan
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
Genes Dev. 2009 Sep 1;23(17):1981-5. doi: 10.1101/gad.1846609.
Many bacterial small regulatory RNAs (sRNAs) pair with mRNA targets, stimulating or inhibiting mRNA stability and/or translation. Regulation of these sRNAs is usually due to tight transcriptional regulation of synthesis.In this issue of Genes & Development and a related paper in Molecular Microbiology, Figueroa-Bossi and colleagues (pp. 2004-2015) and Overgaard and colleagues report a novel regulatory mechanism in which induction of a competing mRNA acts to titrate away the sRNA, allowing expression of an otherwise strongly inhibited target gene.
许多细菌小调节RNA（sRNA）与mRNA靶标配对，刺激或抑制mRNA的稳定性和/或翻译。这些sRNA的调节通常归因于合成过程中的严格转录调控。在本期《基因与发育》以及《分子微生物学》上的一篇相关论文中，菲格罗亚-博西及其同事（第2004 - 2015页）以及奥弗加德及其同事报道了一种新的调节机制，即诱导一种竞争性mRNA来消耗sRNA，从而使原本受到强烈抑制的靶基因得以表达。
