Kaga Tetsuro, Noda Yoshifumi, Asano Masashi, Kawai Nobuyuki, Kajita Kimihiro, Takai Yukiko, Ejima Fumitaka, Hyodo Fuminori, Kato Hiroki, Fukukura Yoshihiko, Matsuo Masayuki
Department of Radiology, Gifu University, Gifu ,Gifu ,Japan.
Department of Frontier Science for Imaging, Gifu University, Gifu ,Gifu ,Japan.
Magn Reson Med Sci. 2024 Aug 6. doi: 10.2463/mrms.mp.2024-0046.
This study aimed to evaluate the feasibility of single-shot echo planar diffusion-weighted imaging with compressed SENSE (EPICS-DWI) for pancreas assessment by comparing with single-shot echo planar DWI with parallel imaging (PI-DWI).
This multicenter prospective study included 27 consecutive participants with untreated pancreatic ductal adenocarcinoma (PDAC) (15 men; mean age, 67 ± 10 years) who underwent pancreatic protocol MRI including both PI-DWI and EPICS-DWI. Two radiologists independently and randomly reviewed the high b-value DWI images and qualitatively assigned confidence scores for overall image quality, image noise, pancreas conspicuity, and PDAC conspicuity using a 5-point scale. One radiologist measured the PDAC-to-pancreas contrast-to-noise-ratio (CNR) on high b-value DWI images and the apparent diffusion coefficient (ADC) value of PDAC. Qualitative and quantitative parameters were compared between PI-DWI and EPICS-DWI using the Wilcoxon signed-rank test.
The confidence scores for overall image quality (P < 0.001 in both radiologists) and image noise (P < 0.001 in both radiologists) were higher in EPICS-DWI than in PI-DWI. The pancreas conspicuity was better in EPICS-DWI than in PI-DWI in one of the radiologists (P = 0.02 and 0.06). The PDAC conspicuity was comparable between PI-DWI and EPICS-DWI (P > 0.99 in both radiologists). The PDAC-to-pancreas CNR was higher in EPICS-DWI than in PI-DWI (P = 0.02), while the ADC value of PDAC in PI-DWI was not significantly different compared to that in EPICS-DWI (P = 0.48).
The image quality and PDAC-to-pancreas CNR was improved in EPICS-DWI compared to PI-DWI. However, the conspicuity and ADC value of PDAC were comparable between PI-DWI and EPICS-DWI.
本研究旨在通过与并行成像单次激发回波平面扩散加权成像（PI-DWI）比较，评估压缩感知单次激发回波平面扩散加权成像（EPICS-DWI）用于胰腺评估的可行性。
这项多中心前瞻性研究纳入了27例未经治疗的胰腺导管腺癌（PDAC）患者（15例男性；平均年龄67±10岁），他们接受了包括PI-DWI和EPICS-DWI的胰腺MRI检查。两名放射科医生独立且随机地回顾高b值DWI图像，并使用5分制对整体图像质量、图像噪声、胰腺清晰度和PDAC清晰度进行定性评分。一名放射科医生在高b值DWI图像上测量PDAC与胰腺的对比噪声比（CNR）以及PDAC的表观扩散系数（ADC）值。使用Wilcoxon符号秩检验比较PI-DWI和EPICS-DWI之间的定性和定量参数。
EPICS-DWI的整体图像质量（两位放射科医生的P均<0.001）和图像噪声（两位放射科医生的P均<0.001）的置信度得分高于PI-DWI。在其中一位放射科医生中，EPICS-DWI中的胰腺清晰度优于PI-DWI（P = 0.02和0.06）。PI-DWI和EPICS-DWI之间的PDAC清晰度相当（两位放射科医生的P均>0.99）。EPICS-DWI中的PDAC与胰腺CNR高于PI-DWI（P = 0.02），而PI-DWI中PDAC的ADC值与EPICS-DWI相比无显著差异（P = 0.48）。
与PI-DWI相比，EPICS-DWI的图像质量和PDAC与胰腺的CNR有所改善。然而，PI-DWI和EPICS-DWI之间的PDAC清晰度和ADC值相当。
