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新冠疫情期间养老院居民的全因死亡率和住院情况:一项基于挪威登记数据的队列研究。

All-cause mortality and hospital admissions for nursing home residents during the COVID-19 pandemic: a Norwegian register-based cohort study.

作者信息

Øien Henning, Gjesvik Jonas, Skyrud Katrine Damgaard, Rotevatn Torill Alise, Grøsland Mari

机构信息

Cluster of Health Services Research, Norwegian Institute of Public Health, Oslo, Norway.

Department of Health Management and Health Economics, University of Oslo, Oslo, Norway.

出版信息

BMC Med. 2024 Aug 7;22(1):318. doi: 10.1186/s12916-024-03523-8.

DOI:10.1186/s12916-024-03523-8
PMID:39113056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11304764/
Abstract

BACKGROUND

This paper investigates the consequences of the COVID-19 pandemic on mortality and hospitalization among nursing home residents in Norway. While existing evidence shows that nursing home residents were overrepresented among COVID-19-related deaths, suggesting inadequate protection measures, this study argues that the observed overrepresentation in mortality and hospitalization may partly stem from the inherent frailty of this demographic. Using nationwide administrative data, we assessed excess deaths and hospitalization by comparing pandemic-era rates to those of a pre-pandemic cohort.

METHODS

We compared mortality and hospitalization rates between a pandemic cohort of nursing home residents as of September 2019 (N = 30,052), and a pre-pandemic cohort as of September 2017 (N = 30,429). Both cohorts were followed monthly for two years, beginning in September 2019 and 2017, respectively. This analysis was conducted at the national level and separately for nursing home residents in areas with low, medium, and high SARS-CoV-2 community transmission. Event studies and difference-in-difference models allowed us to separate the impact of the pandemic on mortality and hospitalization from secular and seasonal changes.

RESULTS

The pandemic cohort experienced a non-significant 0.07 percentage points (95% confidence interval (CI): - 0.081 to 0.221) increase in all-cause mortality during the 18 months following pandemic onset, compared to the pre-pandemic cohort. Moreover, our findings indicate a substantial reduction in hospitalizations of 0.27 percentage points (95% CI: - 0.464 to - 0.135) and a non-significant decrease of 0.80 percentage points (95% CI: - 2.529 to 0.929) in the proportion of nursing home residents hospitalized before death. The effect on mortality remained consistent across regions with both high and low levels of SARS-CoV-2 community transmission.

CONCLUSIONS

Our findings indicate no clear evidence of excess all-cause mortality in Norway during the pandemic, neither nationally nor in areas with high infection rates. This suggests that early implementation of nationwide and nursing home-specific infection control measures during the pandemic effectively protected nursing home residents. Furthermore, our results revealed a decrease in hospitalizations, both overall and prior to death, suggesting that nursing homes adhered to national guidelines promoting on-site treatment for residents.

摘要

背景

本文调查了新冠疫情对挪威养老院居民死亡率和住院率的影响。虽然现有证据表明养老院居民在新冠相关死亡中占比过高,这表明保护措施不足,但本研究认为,观察到的死亡率和住院率过高可能部分源于该人群固有的脆弱性。我们使用全国性行政数据,通过将疫情期间的比率与疫情前队列的比率进行比较,评估了超额死亡和住院情况。

方法

我们比较了2019年9月养老院居民疫情队列(N = 30,052)和2017年9月疫情前队列(N = 30,429)的死亡率和住院率。两个队列分别从2019年9月和2017年9月开始每月随访两年。该分析在国家层面进行,并分别针对新冠病毒社区传播低、中、高地区的养老院居民。事件研究和双重差分模型使我们能够将疫情对死亡率和住院率的影响与长期和季节性变化区分开来。

结果

与疫情前队列相比,疫情队列在疫情开始后的18个月内全因死亡率无显著增加,增幅为0.07个百分点(95%置信区间(CI):-0.081至0.221)。此外,我们的研究结果表明住院率大幅下降0.27个百分点(95% CI:-0.464至-0.135),死亡前住院的养老院居民比例无显著下降,降幅为0.80个百分点(95% CI:-2.529至0.929)。在新冠病毒社区传播水平高和低的地区,对死亡率的影响保持一致。

结论

我们的研究结果表明,在疫情期间,挪威全国范围内以及高感染率地区均没有明显的全因死亡率过高的证据。这表明疫情期间早期实施的全国性和养老院特定的感染控制措施有效地保护了养老院居民。此外,我们的结果显示住院率总体上以及在死亡前均有所下降,这表明养老院遵守了促进为居民提供现场治疗的国家指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/146c/11304764/c1a5b17da77e/12916_2024_3523_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/146c/11304764/3d1b8c812b5a/12916_2024_3523_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/146c/11304764/085daa53473e/12916_2024_3523_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/146c/11304764/c1a5b17da77e/12916_2024_3523_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/146c/11304764/3d1b8c812b5a/12916_2024_3523_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/146c/11304764/085daa53473e/12916_2024_3523_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/146c/11304764/c1a5b17da77e/12916_2024_3523_Fig3_HTML.jpg

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