关于M1型巨噬细胞亚群在口腔癌发生中作用的探讨。
Deliberation concerning the role of M1-type macrophage subset in oral carcinogenesis.
作者信息
Li Chen-Xi, Gong Zhong-Cheng, Yu Jing-Wen
机构信息
Department of Oral and Maxillofacial Oncology & Surgery, School / Hospital of Stomatology, the First Affiliated Hospital of Xinjiang Medical University, Stomatological Research Institute of Xinjiang Uygur Autonomous Region, Urumqi, 830054, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, School of Stomatology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.
出版信息
J Exp Clin Cancer Res. 2024 Aug 8;43(1):220. doi: 10.1186/s13046-024-03128-2.
Over the last decade, accumulating evidence has suggested that tumor-associated macrophages (TAMs) play a significant role in the tumor development. This commentary wishes to highlight the findings by You, et al. that M1-like TAMs could cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma (OSCC) via the IL6/Stat3/THBS1 feedback loop. These unprecedented findings identified M1-like TAMs-regulated processes as potentially tumor-promotion in the context of OSCC immunomicroenvironment.
在过去十年中，越来越多的证据表明肿瘤相关巨噬细胞（TAM）在肿瘤发展中起重要作用。本述评旨在强调You等人的研究结果，即M1样TAM可通过IL6/Stat3/THBS1反馈环引发口腔鳞状细胞癌（OSCC）的间充质/干细胞样表型。这些前所未有的发现表明，在OSCC免疫微环境中，M1样TAM调节的过程可能促进肿瘤发展。
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