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有针对性的本地外展诊所对提高新冠疫苗接种率的影响:英格兰西南部的对照中断时间序列研究

The impact of targeted local outreach clinics to improve COVID-19 vaccine uptake: controlled interrupted time series in South West England.

作者信息

Jones Tim, Adamali Huzaifa, Redaniel Maria Theresa, de Vocht Frank, Tilling Kate, Kenward Charlie, Ben-Shlomo Yoav, Creavin Sam

机构信息

The National Institute for Health Research Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol NHS Foundation Trust, Bristol, BS1 2NT, UK.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2PS, UK.

出版信息

Arch Public Health. 2024 Aug 7;82(1):118. doi: 10.1186/s13690-024-01341-1.

Abstract

BACKGROUND

Outreach clinics were part of efforts to maximise uptake in COVID-19 vaccination.

METHODS

We used controlled interrupted time series, matching on age, sex, deprivation and vaccination eligibility date, to determine the effect of outreach clinics on time to first COVID-19 vaccine, using a population-based electronic health record database of 914,478 people, from December 2020 to December 2021; people living within 1 mile of each outreach clinics were exposed.

RESULTS

50% of 288,473 exposed citizens were white British, and 71% were aged 0-49 years. There was no evidence for an overall statistically significant increase in cumulative percentage vaccinated due to the outreach clinic at 6 weeks, with an overall pooled effect estimate of -0.07% (95% CI: -1.15%, 1.02%). The pooled estimate for increased cumulative vaccine uptake varied slightly depending on how the analysis was stratified; by ethnic group it was - 0.12% (95% CI: -0.90%, 0.66%); by age group it was - 0.06% (95% CI: -0.41%, 0.28%); and by deprivation it was 0.03% (95% CI: -0.74%, 0.79%).

CONCLUSIONS

Living within a mile of an outreach clinic was not associated with higher vaccine uptake. Evaluation of future outreach clinics should consider the relative importance of travel amongst other barriers to accessing vaccines.

摘要

背景

外展诊所是提高新冠疫苗接种率努力的一部分。

方法

我们使用对照中断时间序列,根据年龄、性别、贫困程度和疫苗接种资格日期进行匹配,利用一个基于人群的包含914478人的电子健康记录数据库,来确定外展诊所在首次接种新冠疫苗时间方面的影响,研究时间为2020年12月至2021年12月;居住在每个外展诊所1英里范围内的人被视为暴露组。

结果

在288473名暴露的居民中,50%为英国白人,71%年龄在0至49岁之间。没有证据表明在6周时因外展诊所导致接种累计百分比有总体统计学上的显著增加,总体合并效应估计为-0.07%(95%置信区间:-1.15%,1.02%)。根据分析分层方式的不同,累计疫苗接种增加的合并估计略有差异;按种族分组为-0.12%(95%置信区间:-0.90%,0.66%);按年龄组为-0.06%(95%置信区间:-0.41%,0.28%);按贫困程度为0.03%(95%置信区间:-0.74%,0.79%)。

结论

居住在外展诊所1英里范围内与更高的疫苗接种率无关。对未来外展诊所的评估应考虑出行在获取疫苗的其他障碍中的相对重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f546/11304932/203f7b3a963d/13690_2024_1341_Fig3_HTML.jpg

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