Faculty of Engineering, Universidad Nacional de Colombia, Bogotá, Colombia.
Institute for Multiphase Processes, Leibniz University Hannover, Hannover, Germany.
Int J Artif Organs. 2024 Aug;47(8):633-641. doi: 10.1177/03913988241266088. Epub 2024 Aug 8.
Cardiovascular diseases, particularly myocardial infarction, have significant healthcare challenges due to the limited regenerative capacity of injured heart tissue. Cardiac tissue engineering (CTE) offers a promising approach to repairing myocardial damage using biomaterials that mimic the heart's extracellular matrix. This study investigates the potential of graphene nanopowder (Gnp)-enhanced polycaprolactone (PCL) scaffolds fabricated via electrospinning to improve the properties necessary for effective cardiac repair. This work aimed to analyze scaffolds with varying graphene concentrations (0.5%, 1%, 1.5%, and 2% by weight) to determine their morphological, chemical, mechanical, and biocompatibility characteristics. The results presented that incorporating graphene improves PCL scaffolds' mechanical properties and cellular interactions. The optimal concentration of 1% graphene significantly enhanced mechanical properties and biocompatibility, promoting cell adhesion and proliferation. These findings suggest that Gnp-enhanced PCL scaffolds at this concentration can serve as a potent substrate for CTE providing insights into designing more effective biomaterials for myocardial restoration.
心血管疾病，特别是心肌梗死，由于受伤心脏组织的再生能力有限，因此在医疗保健方面面临重大挑战。心脏组织工程（CTE）提供了一种有前途的方法，可使用模拟心脏细胞外基质的生物材料来修复心肌损伤。本研究旨在通过静电纺丝来研究增强型聚己内酯（PCL）支架的潜力，这些支架中含有不同浓度的石墨烯纳米粉末（Gnp）（重量比为 0.5％、1％、1.5％和 2％），以确定其形态、化学、机械和生物相容性特征。结果表明，加入石墨烯可改善 PCL 支架的机械性能和细胞相互作用。最佳浓度的 1％石墨烯显著提高了机械性能和生物相容性，促进了细胞的黏附和增殖。这些发现表明，在该浓度下，Gnp 增强的 PCL 支架可用作 CTE 的有效基质，为设计更有效的心肌修复生物材料提供了思路。
