Aktar Asma, Bhuia Shimul, Chowdhury Raihan, Ferdous Jannatul, Khatun Muslima, Hasan Sakib Al, Mia Emon, Hasan Rubel, Islam Muhammad Torequl
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
Phytochemistry and Biodiversity Research Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Dhaka, Bangladesh.
Chem Biodivers. 2024 Dec;21(12):e202400874. doi: 10.1002/cbdv.202400874. Epub 2024 Oct 18.
This study evaluates the pharmacological effects of iridoid glucoside loganic acid, a plant constituent with diverse properties, based on literature, and explores the underlying cellular mechanisms for treating several ailments. Data were collected from reliable electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, etc. The results demonstrated the anti-inflammatory, anti-oxidant, and other protective effects of loganic acid on metabolic diseases and disorders such as atherosclerosis, diabetes, and obesity, in addition to its osteoprotective and anticancer properties. The antioxidant activity of loganic acid demonstrates its capacity to protect cells from oxidative damage and mitigates inflammation by reducing the activity of inflammatory cytokines involving TNF-α and IL-6, substantially upregulating the expression of PPAR-γ/α, and decreasing the clinical signs of inflammation-related conditions related to hypertriglyceridemia and atherosclerosis. Meanwhile, loganic acid inhibits bone loss, exhibits osteoprotective properties by increasing mRNA expression levels of bone synthesizing genes such as Alpl, Bglap, and Sp7, and significantly increases osteoblastic proliferation in preosteoblast cells. Loganic acid is an anti-metastatic drug that reduces MnSOD expression, inhibits EMT and metastasis, and prevents cellular migration, proliferation, and invasion in hepatocellular carcinoma cells. However, additional clinical trials are required to assess its safety, efficacy, and human dose.
本研究基于文献评估了环烯醚萜苷马钱子酸（一种具有多种特性的植物成分）的药理作用，并探索了其治疗多种疾病的潜在细胞机制。数据收集自可靠的电子数据库，包括PubMed、Scopus、Web of Science和谷歌学术等。结果表明，马钱子酸除具有骨保护和抗癌特性外，还对动脉粥样硬化、糖尿病和肥胖等代谢性疾病和病症具有抗炎、抗氧化及其他保护作用。马钱子酸的抗氧化活性表明其能够保护细胞免受氧化损伤，并通过降低涉及肿瘤坏死因子-α和白细胞介素-6的炎性细胞因子的活性、大幅上调过氧化物酶体增殖物激活受体-γ/α的表达以及减轻与高甘油三酯血症和动脉粥样硬化相关的炎症相关病症的临床症状来减轻炎症。同时，马钱子酸抑制骨质流失，通过增加骨合成基因如碱性磷酸酶、骨钙素和osterix的mRNA表达水平表现出骨保护特性，并显著增加前成骨细胞中的成骨细胞增殖。马钱子酸是一种抗转移药物，可降低锰超氧化物歧化酶的表达，抑制上皮-间质转化和转移，并阻止肝癌细胞的细胞迁移、增殖和侵袭。然而，需要进行更多的临床试验来评估其安全性、有效性和人体剂量。
