Wang Ling, Zhang Zhengwei, Zhang Haichao, Zhou Minmin, Huang Cheng, Xia Wenjiang, Li Jun, You Hongmei
Department of Pharmacy, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.
Front Immunol. 2024 Jul 24;15:1346446. doi: 10.3389/fimmu.2024.1346446. eCollection 2024.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is one of the fundamental mechanisms of the body's defense, which responds to the abnormal presence of double-stranded DNA in the cytoplasm to establish an effective natural immune response. In addition to detecting microbial infections, the cGAS pathway may be triggered by any cytoplasmic DNA, which is absent from the normal cytoplasm, and only conditions such as senescence and mitochondrial stress can lead to its leakage and cause sterile inflammation. A growing body of research has shown that the cGAS-STING pathway is strongly associated with sterile inflammation. In this study, we reviewed the regulatory mechanisms and biological functions of the cGAS-STING pathway through its involvement in aseptic inflammation in liver disease, kidney disease, and cellular senescence.
环磷酸鸟苷-腺苷合成酶（cGAS）-干扰素基因刺激因子（STING）信号通路是机体防御的基本机制之一，其对细胞质中双链DNA的异常存在做出反应，以建立有效的天然免疫反应。除了检测微生物感染外，cGAS通路可能由正常细胞质中不存在的任何细胞质DNA触发，只有衰老和线粒体应激等情况会导致其泄漏并引发无菌性炎症。越来越多的研究表明，cGAS-STING通路与无菌性炎症密切相关。在本研究中，我们通过cGAS-STING通路参与肝脏疾病、肾脏疾病和细胞衰老中的无菌性炎症，综述了其调控机制和生物学功能。
