用氟氯西林治疗菌血症时出现的焦谷氨酸酸中毒——高阴离子间隙代谢性酸中毒的罕见原因。
Pyroglutamic acidosis in the setting of bacteremia treated with flucloxacillin-An uncommon cause of high anion gap metabolic acidosis.
作者信息
See Aaron Yee Shuen, Lau Ashton Zheng-Boon, Thiruvengadam Srivathsan
机构信息
Medical School University of Western Australia Perth Western Australia Australia.
Internal Medicine Unit Royal Perth Hospital Perth Western Australia Australia.
出版信息
Clin Case Rep. 2024 Aug 7;12(8):e9243. doi: 10.1002/ccr3.9243. eCollection 2024 Aug.
Pyroglutamic acidosis (PGA) or 5-Oxoprolinuria is an uncommon and often overlooked cause of high anion gap metabolic acidosis (HAGMA). This case highlights the importance of systematically approaching HAGMA, and to consider PGA as a differential diagnosis when medications that disrupt the γ-glutamyl cycle such as flucloxacillin and paracetamol are present.
焦谷氨酸酸中毒（PGA）或5-氧脯氨酸尿症是高阴离子间隙代谢性酸中毒（HAGMA）一种罕见且常被忽视的病因。本病例强调了系统分析HAGMA的重要性，以及当存在如氟氯西林和对乙酰氨基酚等干扰γ-谷氨酰循环的药物时，将PGA作为鉴别诊断的必要性。
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