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用氟氯西林治疗菌血症时出现的焦谷氨酸酸中毒——高阴离子间隙代谢性酸中毒的罕见原因。

Pyroglutamic acidosis in the setting of bacteremia treated with flucloxacillin-An uncommon cause of high anion gap metabolic acidosis.

作者信息

See Aaron Yee Shuen, Lau Ashton Zheng-Boon, Thiruvengadam Srivathsan

机构信息

Medical School University of Western Australia Perth Western Australia Australia.

Internal Medicine Unit Royal Perth Hospital Perth Western Australia Australia.

出版信息

Clin Case Rep. 2024 Aug 7;12(8):e9243. doi: 10.1002/ccr3.9243. eCollection 2024 Aug.

DOI:10.1002/ccr3.9243
PMID:39114848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11305870/
Abstract

Pyroglutamic acidosis (PGA) or 5-Oxoprolinuria is an uncommon and often overlooked cause of high anion gap metabolic acidosis (HAGMA). This case highlights the importance of systematically approaching HAGMA, and to consider PGA as a differential diagnosis when medications that disrupt the γ-glutamyl cycle such as flucloxacillin and paracetamol are present.

摘要

焦谷氨酸酸中毒（PGA）或5-氧脯氨酸尿症是高阴离子间隙代谢性酸中毒（HAGMA）一种罕见且常被忽视的病因。本病例强调了系统分析HAGMA的重要性，以及当存在如氟氯西林和对乙酰氨基酚等干扰γ-谷氨酰循环的药物时，将PGA作为鉴别诊断的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ca/11305870/403a634e771f/CCR3-12-e9243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ca/11305870/829f764813d8/CCR3-12-e9243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ca/11305870/6870a82af88b/CCR3-12-e9243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ca/11305870/403a634e771f/CCR3-12-e9243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ca/11305870/829f764813d8/CCR3-12-e9243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ca/11305870/6870a82af88b/CCR3-12-e9243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ca/11305870/403a634e771f/CCR3-12-e9243-g002.jpg

相似文献

1
Pyroglutamic acidosis in the setting of bacteremia treated with flucloxacillin-An uncommon cause of high anion gap metabolic acidosis.用氟氯西林治疗菌血症时出现的焦谷氨酸酸中毒——高阴离子间隙代谢性酸中毒的罕见原因。
Clin Case Rep. 2024 Aug 7;12(8):e9243. doi: 10.1002/ccr3.9243. eCollection 2024 Aug.
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本文引用的文献

1
Pyroglutamate acidosis 2023. A review of 100 cases.焦谷氨酸酸中毒 2023. 100 例回顾。
Clin Med (Lond). 2024 Mar;24(2):100030. doi: 10.1016/j.clinme.2024.100030. Epub 2024 Feb 29.
2
A Review of Bicarbonate Use in Common Clinical Scenarios.碳酸氢盐在常见临床情况中的应用综述。
J Emerg Med. 2023 Aug;65(2):e71-e80. doi: 10.1016/j.jemermed.2023.04.012. Epub 2023 Apr 21.
3
Flucloxacillin and paracetamol induced pyroglutamic acidosis.氟氯西林和对乙酰氨基酚引起焦谷氨酸血症。
BMJ Case Rep. 2021 Jan 8;14(1):e237536. doi: 10.1136/bcr-2020-237536.
4
Pyroglutamic Acidemia: An Underrecognized and Underdiagnosed Cause of High Anion Gap Metabolic Acidosis - A Case Report and Review of Literature.焦谷氨酸血症：高阴离子间隙代谢性酸中毒的一个未被充分认识和诊断的原因——病例报告及文献综述
Cureus. 2019 Jul 24;11(7):e5229. doi: 10.7759/cureus.5229.
5
Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study.焦谷氨酸血症致高阴离子间隙型代谢性酸中毒：一项前瞻性研究。
Sci Rep. 2019 Mar 5;9(1):3554. doi: 10.1038/s41598-019-39257-4.
6
Metabolic Acidosis Due To Pyroglutamic Acid.焦谷氨酸所致代谢性酸中毒
Eur J Case Rep Intern Med. 2018 Oct 24;5(10):000949. doi: 10.12890/2018_000949. eCollection 2018.
7
Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen.与治疗用对乙酰氨基酚相关的复发性焦谷氨酸血症。
Am J Med Sci. 2018 Apr;355(4):387-389. doi: 10.1016/j.amjms.2017.08.001. Epub 2017 Aug 3.
8
Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study.对乙酰氨基酚（扑热息痛）与氟氯西林联合使用导致代谢性酸中毒？一例病例报告及回顾性研究
Eur J Clin Pharmacol. 2017 Nov;73(11):1459-1465. doi: 10.1007/s00228-017-2311-6. Epub 2017 Aug 7.
9
Acquired 5-oxoproline acidemia successfully treated with N-acetylcysteine.N-乙酰半胱氨酸成功治疗获得性5-氧脯氨酸血症。
Proc (Bayl Univ Med Cent). 2017 Apr;30(2):169-170. doi: 10.1080/08998280.2017.11929570.
10
Physiological approach to assessment of acid-base disturbances.酸碱平衡紊乱评估的生理学方法。
N Engl J Med. 2015 Jan 8;372(2):195. doi: 10.1056/NEJMc1413880.