Yu Yanmei, Tan Tongcai, Yang Wei, Xu Zhitao, Liu Yong
Department of Rehabilitation Medicine, Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
PLoS One. 2024 Aug 8;19(8):e0308288. doi: 10.1371/journal.pone.0308288. eCollection 2024.
Inflammation is an important causative factor of obesity. This study aimed to explore the possible association between the systemic immune-inflammatory index, a novel indicator of inflammation, and obesity.
Data were collected from 4395 participants of the National Health and Nutrition Examination Survey 2017-2018 aged ≥ 20 years. The systemic immune-inflammatory index was calculated by multiplying the platelet count by the neutrophil-to-lymphocyte ratio. Obesity was defined as a body mass index ≥ 30 kg/m2.
A significant positive correlation was observed between the systemic immune-inflammatory index and body mass index following multivariate linear regression analysis (β = 1.75; 95% confidence interval = 1.16-2.33), which was greatest in adults aged < 60 years without hypertension and diabetes. Smoothed curve fitting and threshold effect analysis were used to characterize the nonlinear association between the systemic immune-inflammatory index and body mass index, and the inflection point was found to be 729.3.
The systemic immune-inflammatory index is positively associated with body mass index among adults in the United States and has the potential to enhance efforts to prevent adult obesity.
炎症是肥胖的一个重要致病因素。本研究旨在探讨一种新的炎症指标——全身免疫炎症指数与肥胖之间可能存在的关联。
收集了2017 - 2018年美国国家健康与营养检查调查中4395名年龄≥20岁参与者的数据。全身免疫炎症指数通过血小板计数乘以中性粒细胞与淋巴细胞比值来计算。肥胖定义为体重指数≥30kg/m²。
多变量线性回归分析后发现全身免疫炎症指数与体重指数之间存在显著正相关（β = 1.75；95%置信区间 = 1.16 - 2.33），在年龄<60岁且无高血压和糖尿病的成年人中这种相关性最强。采用平滑曲线拟合和阈值效应分析来描述全身免疫炎症指数与体重指数之间的非线性关联，发现拐点为729.3。
在美国成年人中，全身免疫炎症指数与体重指数呈正相关，并且有可能加强预防成人肥胖的工作。
