Veress B, el Hassan A M
Acta Pathol Microbiol Immunol Scand A. 1985 Nov;93(6):331-4. doi: 10.1111/j.1699-0463.1985.tb03959.x.
The presence and distribution of S-100 protein antigen and lysozyme were investigated by the immunoperoxidase method in paraffin sections of 13 cases of chronic cutaneous leishmaniasis from Saudi Arabia. Varying numbers of S-100+lys- histiocytic reticulum cells were found in the dense inflammatory infiltrate in 11 out of 13 cases. These cells were considerably more numerous in the lesions dominated by cells of the mononuclear phagocytic system and granulomata than in the cases with plasma cellular or lymphocytic predominance. Activated lys+ macrophages, epithelioid cells, and multinucleated giant cells were always S-100-. Around the granulomata several S-100+lys- histiocytic reticulum cells could be found. These findings suggest that antigen-presenting cells are present in the inflammatory infiltrate of cutaneous leishmaniasis.
采用免疫过氧化物酶法对来自沙特阿拉伯的13例慢性皮肤利什曼病石蜡切片中的S-100蛋白抗原和溶菌酶的存在及分布情况进行了研究。在13例中的11例致密炎性浸润中发现了数量不等的S-100+lys-组织细胞性网状细胞。在以单核吞噬系统细胞和肉芽肿为主的病变中，这些细胞的数量比以浆细胞或淋巴细胞为主的病例中要多得多。活化的lys+巨噬细胞、上皮样细胞和多核巨细胞总是S-100阴性。在肉芽肿周围可发现数个S-100+lys-组织细胞性网状细胞。这些发现提示抗原呈递细胞存在于皮肤利什曼病的炎性浸润中。
