阿莫西林-克拉维酸与复方新诺明治疗成人急性尿路感染的随机对照研究
Randomized comparative study of amoxicillin-clavulanic acid and co-trimoxazole in the treatment of acute urinary tract infections in adults.
作者信息
Karachalios G N
出版信息
Antimicrob Agents Chemother. 1985 Nov;28(5):693-4. doi: 10.1128/AAC.28.5.693.
The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infecting organisms were equivalent in both groups of patients. Escherichia coli was the predominant bacteria pathogen in both groups. Both drugs resulted in clinical improvement in 100% of the patients; bacteriological cure after the termination of therapy was 95% with amoxicillin-clavulanic acid and 83% with co-trimoxazole (P less than 0.001). Side effects were not severe enough to necessitate discontinuation of the antimicrobial agents. Amoxicillin-clavulanic acid is effective and safe therapy for acute urinary tract infections caused by susceptible bacteria.
在治疗急性尿路感染方面，对阿莫西林 - 克拉维酸与复方新诺明的疗效和安全性进行了比较。共有104例（平均年龄52岁）有急性尿路感染临床和实验室证据的患者纳入该研究。两组患者的特征和感染微生物相当。大肠杆菌是两组中的主要细菌病原体。两种药物均使100%的患者临床症状改善；治疗结束后，阿莫西林 - 克拉维酸的细菌学治愈率为95%，复方新诺明为83%（P小于0.001）。副作用不够严重，无需停用抗菌药物。阿莫西林 - 克拉维酸是治疗由敏感细菌引起的急性尿路感染的有效且安全的疗法。
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