大肠杆菌中的β-内酰胺酶与β-内酰胺抗性
beta-Lactamases and beta-lactam resistance in Escherichia coli.
作者信息
Jacoby G A, Sutton L
出版信息
Antimicrob Agents Chemother. 1985 Nov;28(5):703-5. doi: 10.1128/AAC.28.5.703.
Abstract
Escherichia coli strains determining 17 different plasmid-determined beta-lactamases were tested for resistance to new broad-spectrum beta-lactam antibiotics. Several beta-lactamases demonstrated enhanced resistance to cefamandole but only low-level resistance to other agents. High production of cloned E. coli chromosomal beta-lactamase, however, provided resistance to cefamandole, cefoxitin, cefotaxime, ceftazidime, and aztreonam but not to BMY-28142 or imipenem.
摘要
对携带17种不同质粒介导β-内酰胺酶的大肠杆菌菌株进行了新型广谱β-内酰胺抗生素的耐药性测试。几种β-内酰胺酶对头孢孟多耐药性增强，但对其他药物仅表现出低水平耐药。然而，大肠杆菌染色体β-内酰胺酶的高表达赋予了对头孢孟多、头孢西丁、头孢噻肟、头孢他啶和氨曲南的耐药性，但对BMY-28142或亚胺培南无耐药性。
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