耐β-内酰胺类大肠杆菌K-12突变体的筛选与鉴定
Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants.
作者信息
Jaffé A, Chabbert Y A, Derlot E
出版信息
Antimicrob Agents Chemother. 1983 Apr;23(4):622-5. doi: 10.1128/AAC.23.4.622.
Abstract
beta-Lactam-resistant mutants of Escherichia coli K-12 were selected by using 12 different beta-lactam derivatives. The mutants fell into three categories showing (i) altered permeation through reduction or loss of outer membrane porin proteins (including ompF, ompR, and envZ alleles); (ii) increase in the rate of synthesis of chromosomally mediated beta-lactamase; or (iii) defective synthesis or action of cyclic adenosine 3',5'-phosphate (cya and crp alleles).
摘要
利用12种不同的β-内酰胺衍生物筛选出了大肠杆菌K-12的β-内酰胺抗性突变体。这些突变体分为三类，分别表现为：(i) 通过减少或丧失外膜孔蛋白（包括ompF、ompR和envZ等位基因）而导致通透性改变；(ii) 染色体介导的β-内酰胺酶合成速率增加；或(iii) 环腺苷酸3',5'-磷酸（cya和crp等位基因）合成或作用缺陷。
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本文引用的文献
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Mutants of Escherichia coli that are resistant to certain beta-lactam compounds lack the ompF porin.对某些β-内酰胺化合物具有抗性的大肠杆菌突变体缺乏外膜孔蛋白F（ompF）。
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