头孢他啶在老年志愿者中的药代动力学。
Pharmacokinetics of ceftazidime in elderly volunteers.
作者信息
LeBel M, Barbeau G, Vallee F, Bergeron M G
出版信息
Antimicrob Agents Chemother. 1985 Nov;28(5):713-5. doi: 10.1128/AAC.28.5.713.
Abstract
The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in six elderly volunteers and 12 young subjects. Serum and urine samples were collected in serial order for 24 h and assayed by high-pressure liquid chromatography. The ceftazidime renal clearance was reduced in elderly subjects, a symptom related to normal aging of the kidneys. The decrease in volume of distribution in the elderly group may be explained by a reduction in total body water and an increase in fat tissue. Dosage adjustment is probably not necessary for otherwise healthy elderly patients requiring ceftazidime.
摘要
对6名老年志愿者和12名年轻受试者静脉注射1克头孢他啶后的药代动力学进行了研究。按顺序连续24小时采集血清和尿液样本，并用高压液相色谱法进行分析。老年受试者的头孢他啶肾清除率降低，这是与肾脏正常老化相关的症状。老年组分布容积的减少可能是由于总体液减少和脂肪组织增加所致。对于其他方面健康但需要使用头孢他啶的老年患者，可能无需调整剂量。
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