Beyond 25 years of biomedical innovation in nano-bioelectronics.

Nano-bioelectronics, which blend the precision of nanotechnology with the complexity of biological systems, are evolving with innovations such as silicon nanowires, carbon nanotubes, and graphene. These elements serve applications from biochemical sensing to brain-machine interfacing. This review examines nano-bioelectronics' role in advancing biomedical interventions and discusses their potential in environmental monitoring, agricultural productivity, energy efficiency, and creative fields. The field is transitioning from molecular to ecosystem-level applications, with research exploring complex cellular mechanisms and communication. This fosters understanding of biological interactions at various levels, such as suggesting transformative approaches for ecosystem management and food security. Future research is expected to focus on refining nano-bioelectronic devices for integration with biological systems and on scalable manufacturing to broaden their reach and functionality.