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随机实验性基于人群的研究,评估宫颈癌筛查的接受度、完成度和偏好。

Randomized experimental population-based study to evaluate the acceptance and completion of and preferences for cervical cancer screening.

机构信息

Molecular Oncology Research Centre, Barretos Cancer Hospital, Barretos, Brazil.

Biostatistics, Centre for Teaching and Research, Beneficência Portuguesa de São Paulo, São Paulo (SP), Brazil.

出版信息

PLoS One. 2024 Aug 9;19(8):e0306130. doi: 10.1371/journal.pone.0306130. eCollection 2024.

Abstract

Cervical cancer has high incidence and mortality rates, especially in less-developed countries. Prevention methods are well established, but there are still barriers preventing some Brazilian women from undergoing a Pap sample. The objective of the study was to evaluate the acceptance, preferences and completion of four screening methods. This has an experimental design (community trial). A total of 164 participants who had never had a Pap sample or had not had one for more than three years were included. The city's urban area was stratified by census tracts and divided according to income and education levels. Women belonging to the lower-income strata were considered in the study. Random blocks were numbered into five intervention groups (Group 1- Pap sample at the hospital; Group 2- Pap sample in the mobile unit; Group 3- urine self-collection; Group 4- vaginal self-collection; Group 5- woman's choice). Only 164 women met all of the eligibility criteria (15.3%). Most of them accepted the assigned method (92%), but only 84% of the women completed the collection step. The acceptance rates were as follows: Group 1 (100%), Group 2 (64.5%), Group 3 (100%) and Group 4 (91.4%). In Group 5, the women's preferences were distributed as follows: examination performed at the hospital, 13 women (33.3%); examination performed at the mobile unit, 11 women (28.2%); urine self-collection, 11 women (28.2%); and vaginal self-collection, 4 women (10.3%). This study suggests that methods that allow cervical sampling collected near the women's domicile might improve the acceptance and completion of preventive tests. This finding is relevant for the development of new cervical cancer screening strategies.

摘要

宫颈癌发病率和死亡率高,尤其是在欠发达国家。预防方法已经确立,但仍有一些巴西女性由于某些原因无法进行巴氏涂片检查。本研究旨在评估四种筛查方法的接受度、偏好和完成情况。这是一项实验设计(社区试验)。共纳入 164 名从未进行过巴氏涂片检查或超过三年未进行过巴氏涂片检查的参与者。根据收入和教育水平,将城市的市区按普查区分层,并进行分组。研究对象为收入较低阶层的女性。将随机块编号分为五个干预组(第 1 组-医院进行巴氏涂片检查;第 2 组-移动单位进行巴氏涂片检查;第 3 组-尿液自我采集;第 4 组-阴道自我采集;第 5 组-女性选择)。只有 164 名女性符合所有入选标准(15.3%)。她们大多数接受了分配的方法(92%),但只有 84%的女性完成了采集步骤。接受率如下:第 1 组(100%)、第 2 组(64.5%)、第 3 组(100%)和第 4 组(91.4%)。在第 5 组中,女性的偏好分布如下:医院检查 13 人(33.3%);移动单位检查 11 人(28.2%);尿液自我采集 11 人(28.2%);阴道自我采集 4 人(10.3%)。本研究表明,允许在女性住所附近进行宫颈采样的方法可能会提高预防性检查的接受度和完成度。这一发现对于制定新的宫颈癌筛查策略具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e4/11315343/96cad464b64a/pone.0306130.g001.jpg

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