Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Department of Anesthesiology and Pain medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Medicine (Baltimore). 2024 Aug 9;103(32):e39230. doi: 10.1097/MD.0000000000039230.
Percutaneous lumbar nucleoplasty (PLN) and intradiscal electrothermal therapy (IDET) are effective treatment options for discogenic low back pain (D-LBP). We evaluated the effectiveness of PLN and IDET and the positive predictive factors associated with intradiscal procedures. We reviewed the medical records of 205 patients who underwent IDET or PLN in patients with D-LBP followed by positive provocation discography. A successful outcome was defined as ≥ 50% pain relief on the numerical rating scale (NRS) pain score at the 6-month follow-up visit. The relationship between the outcome of the intradiscal procedure and clinical variables was investigated using multivariate analyses. Of the 142 patients (89 with PLN and 53 with IDET), 86 (60.5%) experienced a successful outcome, which was more substantial in PLN (n = 61, 68.5%) than in IDET (n = 25, 47.2%; P = .010). The high-grade Modified Dallas Discogram Scale in provocation discography and a procedure at the L3/L4 spinal level were independent positive predictors of successful outcomes (P = .023 and .010, respectively). Coexisting psychiatric disorders, such as depression and anxiety, were negative predictors of successful treatment (P = .007). No serious complications related to the intradiscal procedures were reported during the 6-month follow-up period. PLN and IDET might be effective for managing low back pain (LBP) from internal disc disruption (IDD). The high-grade Modified Dallas Discogram, a procedure at the L3/4 spinal level, and the absence of neuropsychiatric disorders could be positive factors for the successful outcome of the intradiscal procedure.
经皮腰椎间盘髓核成形术(PLN)和椎间盘内电热疗法(IDET)是治疗椎间盘源性下腰痛(D-LBP)的有效方法。我们评估了 PLN 和 IDET 的有效性,以及与椎间盘内手术相关的阳性预测因素。我们回顾了 205 例经皮椎间盘髓核切除术或 IDET 治疗后行阳性诱发性椎间盘造影术的 D-LBP 患者的病历。成功的结果定义为在 6 个月随访时数字评定量表(NRS)疼痛评分≥50%的疼痛缓解。使用多变量分析研究了椎间盘内手术结果与临床变量之间的关系。在 142 例患者(PLN 89 例,IDET 53 例)中,86 例(60.5%)获得了成功的结果,PLN(n=61,68.5%)明显优于 IDET(n=25,47.2%;P=0.010)。诱发性椎间盘造影术的改良达拉斯椎间盘造影分级高和 L3/L4 脊柱水平的手术是成功结果的独立阳性预测因素(P=0.023 和.010)。共存的精神疾病,如抑郁和焦虑,是成功治疗的负面预测因素(P=0.007)。在 6 个月的随访期间,没有与椎间盘内手术相关的严重并发症报告。PLN 和 IDET 可能对治疗内部椎间盘破裂(IDD)引起的下腰痛(LBP)有效。高分级改良达拉斯椎间盘造影、L3/4 脊柱水平的手术以及无神经精神疾病可能是椎间盘内手术成功的积极因素。