The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Medicine (Baltimore). 2024 Aug 9;103(32):e39277. doi: 10.1097/MD.0000000000039277.
Traumatic brain injury frequently leads to prolonged coma, posing significant medical management challenges. Complementary therapies, including traditional Chinese herbal medicine, have been investigated as potential interventions in comatose patients. Chinese aromatic herbs, such as Borneolum (Bingpian), Moschus (Shexiang), and Acori tatarinowii rhizoma (Shichangpu), have long been believed to be "resuscitation with aromatics" based on traditional Chinese medicines theory.
A 16-year-old male was admitted to the intensive rehabilitation unit for further treatment due to prolonged coma and frequent seizures following traumatic brain injury.
Western medicine diagnosed the patient as coma, diffuse axonal injury, and epilepsy. According to traditional Chinese medicine theory, the syndrome differentiation indicates a Yin-closed disease.
According to the patient's condition, we use the Chinese aromatic herbs as a complementary therapy.
Following a month-long administration, the patient's consciousness and electroencephalogram (EEG) background progressively improved. A 6-month follow-up demonstrated full arousal, though with ambulatory EEG revealing mild to moderate abnormality in the background.
The addition of Chinese aromatic herbs appears to have a beneficial effect on the patient's consciousness and EEG background. This could be attributed to the herbs' inherent pharmacological properties, as well as their potential to enhance the permeability of the blood-brain barrier to other drugs. This makes them a promising option for complementary therapy.
创伤性脑损伤常导致长时间昏迷,给医疗管理带来巨大挑战。补充疗法,包括中药,已被研究用于昏迷患者。根据传统中药理论,芳香开窍中药如冰片、麝香和石菖蒲,长期以来一直被认为具有“芳香开窍”的作用。
一名 16 岁男性因创伤性脑损伤后长时间昏迷和频繁癫痫发作,被收入重症康复病房进一步治疗。
患者昏迷,弥漫性轴索损伤,癫痫。根据中医理论,辨证为阴闭证。
根据患者病情,采用芳香开窍中药作为补充治疗。
治疗一个月后,患者意识和脑电图(EEG)背景逐渐改善。6 个月随访时,患者完全觉醒,但动态脑电图显示背景轻度至中度异常。
芳香开窍中药的应用似乎对患者的意识和 EEG 背景有有益影响。这可能归因于草药的固有药理学特性,以及它们增强血脑屏障对其他药物通透性的潜力。因此,它们是一种有前途的补充治疗选择。