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罗托宁A、B和E的研究最新进展

Recent Advances in the Research on Luotonins A, B, and E.

作者信息

Gettler Ján, Markovič Martin, Koóš Peter, Gracza Tibor

机构信息

Department of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovakia.

出版信息

Molecules. 2024 Jul 26;29(15):3522. doi: 10.3390/molecules29153522.

Abstract

This digest review summarises the most recent progress in the study on luotonins A, B and E. The literature covered in this overview spans from January 2012 to April 2024 and presents synthetic methodologies for the assembly of the quinolinopyrrolo-quinazoline scaffold, the structural motifs present in luotonins A, B, and E, and the evaluation of the biological activities of their derivatives and structural analogues.

摘要

本综述总结了鲁托宁A、B和E研究的最新进展。本综述涵盖的文献时间跨度从2012年1月至2024年4月,介绍了喹啉并吡咯并喹唑啉支架(鲁托宁A、B和E中存在的结构基序)的合成方法,以及其衍生物和结构类似物的生物活性评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5f/11314610/4bbbd29d9a20/molecules-29-03522-g001.jpg

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Rapid Synthesis of Luotonin A Derivatives via Synergistic Visible-Light Photoredox and Acid Catalysis.
J Org Chem. 2022 Jan 21;87(2):1302-1312. doi: 10.1021/acs.joc.1c02617. Epub 2022 Jan 11.
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Redox Condensations of -Nitrobenzaldehydes with Amines under Mild Conditions: Total Synthesis of the Vasicinone Family.
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A-ring and E-ring modifications of the cytotoxic alkaloid Luotonin A: Synthesis, computational and biological studies.
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