Servicio de Endocrinología, Hospital de La Santa Creu i Sant Pau, 08041 Barcelona, Spain.
CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 28029 Madrid, Spain.
Nutrients. 2024 Jul 31;16(15):2487. doi: 10.3390/nu16152487.
Outcomes of bariatric surgery (BS) in patients with schizophrenia are poorly understood. We aimed to analyze the effects of BS in patients with schizophrenia (SZ) or schizoaffective disorder (SZA).
This was a multicenter, retrospective case-control study in patients with SZ or SZA who had undergone BS in seven public referral hospitals in Spain. Controls without psychiatric comorbidity were selected in a 1:4 ratio. Detailed clinical and biochemical data were collected preoperatively and at 12, 24, 36, 48, and 60 months after BS.
Twenty patients with SZ ( = 15; 75%) or SZA ( = 5; 25%) and 80 matched controls were studied. There were no differences between patients and controls concerning the evolution of the percentage of total weight loss. The remission rate of the main comorbidities was similar between groups except for hypertension, which was lower in patients with a psychotic disorder from year 3. There were no mortalities within 30 days of surgery in either group. The psychiatric medication burden did not change during follow-up.
BS is safe and effective in carefully selected patients with SZ. The course of the psychiatric disease does not seem to be worsened by the procedure.
肥胖症手术（BS）在精神分裂症患者中的效果仍不清楚。我们旨在分析 BS 对精神分裂症（SZ）或分裂情感性障碍（SZA）患者的影响。
这是一项在西班牙 7 家公立医院进行的多中心、回顾性病例对照研究，纳入了接受 BS 的 SZ 或 SZA 患者。按照 1:4 的比例选择无精神共病的对照组。在 BS 术前、术后 12、24、36、48 和 60 个月时收集详细的临床和生化数据。
研究纳入了 20 例 SZ（ = 15；75%）或 SZA（ = 5；25%）患者和 80 名匹配对照者。患者和对照组在体重减轻百分比的演变方面没有差异。除了从第 3 年开始高血压的缓解率较低外，两组主要共病的缓解率相似。两组在手术后 30 天内均无死亡病例。随访期间，精神科药物负担没有变化。
BS 对经过精心选择的 SZ 患者是安全且有效的。该手术似乎不会使精神疾病的病程恶化。
