Wang Fan-Fan, Huang Guo-Bao, Lu Cai-Hong, Chen Li-Jun, Chen Hui-Zhen, Luo Meng-Qin, Tao Ping-Fang, Tan Ming-Xiong, Qin Feng
Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, Yulin, P. R. China.
Nat Prod Res. 2024 Aug 10:1-5. doi: 10.1080/14786419.2024.2390614.
Asperphenol A (), a new isoprenyl-phenol-type meroterpenoid, was isolated from the mangrove endophytic fungus sp. GXNU-Y65 together with five known compounds (-. All structures were assigned using extensive NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds were evaluated for their cytotoxic activity against A549 and T24 human cancer cell lines. Among them, compounds and exhibited moderate inhibitory activities against T24 cancer cell lines with the IC values of 26.71 and 43.50 μM, respectively.
从红树林内生真菌GXNU - Y65中分离出一种新的异戊烯基 - 苯酚型半萜类化合物asperphenol A（），同时还分离出了五种已知化合物（ - ）。所有结构均通过广泛的核磁共振光谱数据和电子圆二色性（ECD）计算确定。评估了化合物对A549和T24人癌细胞系的细胞毒性活性。其中，化合物和对T24癌细胞系表现出中等抑制活性，IC值分别为26.71和43.50μM。
