From the Colorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
From the Department of Surgery, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia.
Ann Saudi Med. 2024 Jul-Aug;44(4):255-263. doi: 10.5144/0256-4947.2024.255. Epub 2024 Aug 1.
The appendix is a small organ with no particular known function. Primary appendiceal neoplasms (ANs) are rare. While the prevalence is increasing worldwide over the past two decades, no apparent increase in the prevalence of ANs has been reported in the Arabian Gulf States. Recently, a significant decline in the age at diagnosis of some types of ANs has been reported worldwide, with a female predominance.
Evaluate the prevalence and clinicopathological characteristics of ANs within our institution in Saudi Arabia and compare them to limited existing studies from different regions as well as the Arabian Gulf States.
Retrospective cohort.
Tertiary care center in Riyadh.
All patients who underwent appendectomy and had the appendix submitted for histopathological evaluation between May 2015 and June 2020 were included to allow for a follow-up of 5 years or more at the time of data collection.
Demographics, clinical presentations, surgical interventions, histopathological findings, complications, and recurrence rates.
25 AN patients.
Of 1110 patients, 25 had ANs (13 female and 12 male participants) with a mean (standard deviation) age of 54.6 (14.1) years. Only 40% presented with acute appendicitis, 64% had comorbidities, and less than 50% underwent laparoscopic appendectomy. Histopathologically, 72% were low-grade appendiceal mucinous neoplasms (LAMNs). Complications were minimal grades (Clavien-Dindo classification), with 80% experiencing none. The mean hospital stay was 9.96 days. Local recurrence occurred in 8% of cases, and distant metastasis was documented in one adenocarcinoma case. However, the 5-year overall and disease-free survival rates were 88% and 80%, respectively.
The incidence of ANs is increasing in Saudi Arabia with the higher prevalence of LAMNs. The pathological examination of the resected appendix played a pivotal role in the diagnosis of ANs.
Data collected retrospectively, a single institution, and a small population.
阑尾是一个没有特定已知功能的小器官。原发性阑尾肿瘤（ANs）很少见。尽管在过去的二十年中，全球的患病率一直在增加，但在阿拉伯海湾国家，没有报告 ANs 患病率明显增加。最近，全球范围内报告了一些类型的 ANs 的诊断年龄显著下降，女性居多。
评估我们在沙特阿拉伯的机构内 ANs 的患病率和临床病理特征，并将其与来自不同地区以及阿拉伯海湾国家的有限现有研究进行比较。
回顾性队列研究。
利雅得的三级保健中心。
所有在 2015 年 5 月至 2020 年 6 月期间接受阑尾切除术且阑尾送检行组织病理学评估的患者均被纳入研究，以便在数据收集时进行至少 5 年的随访。
人口统计学、临床表现、手术干预、组织病理学发现、并发症和复发率。
25 例 AN 患者。
在 1110 例患者中，有 25 例（13 例女性和 12 例男性）患有 ANs，平均（标准差）年龄为 54.6（14.1）岁。只有 40%的患者表现为急性阑尾炎，64%的患者有合并症，不到 50%的患者接受了腹腔镜阑尾切除术。组织病理学上，72%的患者为低级别阑尾粘液性肿瘤（LAMNs）。并发症为轻度（Clavien-Dindo 分级），80%的患者无并发症。平均住院时间为 9.96 天。局部复发发生在 8%的病例中，1 例腺癌患者发生远处转移。然而，5 年总生存率和无病生存率分别为 88%和 80%。
沙特阿拉伯的 ANs 发病率正在增加，其中 LAMNs 的患病率较高。切除阑尾的病理检查对 ANs 的诊断起着关键作用。
数据是回顾性收集的，研究是在一家机构进行的，而且样本量较小。
