University of Tunis El Manar, Faculty of Medicine of Tunis, 1007, Department A, National Institute of Nutrition and Food Technology of Tunis, Tunisia.
University of Tunis El Manar, Higher School of Health Sciences and Techniques of Tunis, 1007, Tunisia.
Tunis Med. 2024 Aug 5;102(8):465-471. doi: 10.62438/tunismed.v102i8.4965.
Sarcopenia is a clinical condition defined as low skeletal muscle mass and function. It has been identified and described as a geriatric syndrome, but it may arise in individuals with obesity at any age.
screen for sarcopenia in obese adults and identify the nutritional, clinical and biological risk factors associated with the development of sarcopenic obesity (SO+).
Descriptive cross-sectional study, including 53 obese patients. Screening for sarcopenia has been established according to pathological thresholds proposed by the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO).
Mean age was 44.34±13.51 years. Prevalence of Sarcopenia was 7.5% (SO+). The average intakes of calorie, lipids and saturated fatty acids were higher in SO+. A statistically significant relationship was found between low skeletal muscle mass (SMM/W) and the average intake of vitamin PP (p=0.014) and vitamin B9 (p=0.009). Mean BMI (45.86 kg/m² for SO+ versus 39.29 kg/m² for SO-; p=0.03) and mean visceral fat (16.55 l for SO+, versus 10.93 l for SO-; p=0.043) were significantly higher in SO+. A statistically significant relationship was found between insulin resistance and low (SMM/W), as attested by mean insulinemia (28.81 µIU/mL for low SMM/W, versus 14.48 µIU/mL for normal SMM/W; p=0.004) and HOMA index (7.94 for low SMM/W, versus 3.49 for normal SMM/W; p=0.002), which were higher in cases of low (SMM/W).
We recommend promoting a balanced, low-energy-density diet to improve insulin sensibility and thus reduce the risk of sarcopenia. Regular physical activity is also strongly recommended.
肌少症是一种以骨骼肌量和功能低下为特征的临床病症。肌少症已被确定为一种老年综合征，但它也可能在任何年龄的肥胖个体中发生。
筛查肥胖成年人的肌少症，并确定与肌少症性肥胖（SO+）发生相关的营养、临床和生物学危险因素。
这是一项描述性的横断面研究，共纳入了 53 名肥胖患者。肌少症的筛查是根据欧洲临床营养与代谢学会（ESPEN）和欧洲肥胖研究协会（EASO）提出的病理阈值来确定的。
患者的平均年龄为 44.34±13.51 岁。肌少症的患病率为 7.5%（SO+）。SO+组的热量、脂类和饱和脂肪酸的平均摄入量较高。低骨骼肌质量（SMM/W）与烟酸（PP）和维生素 B9 的平均摄入量呈显著负相关（p=0.014 和 p=0.009）。SO+组的平均 BMI（45.86 kg/m²）和平均内脏脂肪（16.55 l）明显高于 SO-组（分别为 39.29 kg/m²和 10.93 l，p=0.03 和 p=0.043）。胰岛素抵抗与低 SMM/W 呈显著正相关，表现为低 SMM/W 时的平均胰岛素血症（28.81 µIU/mL，正常 SMM/W 时为 14.48 µIU/mL；p=0.004）和 HOMA 指数（低 SMM/W 时为 7.94，正常 SMM/W 时为 3.49；p=0.002）均较高。
我们建议促进均衡、低能量密度的饮食，以改善胰岛素敏感性，从而降低肌少症的风险。还强烈建议定期进行身体活动。
