Aljuraiban Ghadeer S, Alharbi Fahad J, Aljohi Ali O, Almeshari Abdullah Z, Al-Musharraf Sara Ibrahim, Aldhwayan Madhawi M, Alshaikh Fahdah, Abulmeaty Mahmoud
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11362, Saudi Arabia.
Department of Central Military Laboratory & Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Int J Gen Med. 2024 Aug 6;17:3395-3402. doi: 10.2147/IJGM.S469147. eCollection 2024.
High blood pressure (BP) is a major risk factor for cardiovascular disease. The triglyceride-glucose (TyG) index is a useful tool for identifying insulin resistance at an early stage and has been proposed as a cost-effective predictor for hypertension. However, available studies are limited. This study aims to investigate the association between the TyG index and BP.
Retrospective hospital data of a large cohort (n=1596) of adults aged ≥18 in Saudi Arabia were analyzed. The TyG index was calculated. Lipid markers, systolic BP (SBP), diastolic BP (DBP), and body mass index (BMI) were included.
Across quartiles of the TyG index, SBP was significantly higher in those with higher vs lower TyG (p<0.03). No significant association was observed for DBP. A 2-SD higher SBP was significantly associated with a TyG difference of 1.7 (95% CI: 0.1, 3.3). In subgroup analysis, the relationship prevailed in females only [1.8 (95% CI: 0.3, 3.3)]. Across BMI categories (normal, overweight, obesity), the association between SBP and TyG was observed in participants with obesity only.
The TyG index may act as a cost-effective predictive marker for high blood pressure, especially among specific subgroups. Future prospective studies are needed to confirm this relationship.
高血压是心血管疾病的主要危险因素。甘油三酯-葡萄糖（TyG）指数是早期识别胰岛素抵抗的有用工具，并已被提议作为高血压的一种经济有效的预测指标。然而，现有研究有限。本研究旨在探讨TyG指数与血压之间的关联。
分析了沙特阿拉伯≥18岁的一大群成年人（n = 1596）的回顾性医院数据。计算了TyG指数。纳入了血脂指标、收缩压（SBP）、舒张压（DBP）和体重指数（BMI）。
在TyG指数的四分位数范围内，TyG较高者的SBP显著高于TyG较低者（p < 0.03）。未观察到DBP有显著关联。SBP每升高2个标准差与TyG差异1.7显著相关（95%置信区间：0.1，3.3）。在亚组分析中，这种关系仅在女性中存在[1.8（95%置信区间：0.3，3.3）]。在不同BMI类别（正常、超重、肥胖）中，仅在肥胖参与者中观察到SBP与TyG之间的关联。
TyG指数可能是高血压的一种经济有效的预测指标，尤其是在特定亚组中。未来需要进行前瞻性研究来证实这种关系。
