Möller C
Ups J Med Sci. 1985;90(3):293-8. doi: 10.3109/03009738509178485.
A new, topical anaesthetic formulation, EMLA 5% cream (Eutectic Mixture of Local Anaesthetics), and placebo have been compared in a randomized double-blind study of 51 children. The objectives were to test if EMLA diminishes pain from venipuncture, to evaluate possible adverse reactions, and to determine if there is any influence upon the ease with which the insertion procedure is carried out. Pain was evaluated using a three-graded verbal rating scale. EMLA relieved pain significantly better than placebo (p less than 0.001), and the procedure was considered to be easier after EMLA treatment. No oedema occurred, but a few cases of local redness and paleness were observed after EMLA treatment. However, these reactions were clinically insignificant. It is concluded that EMLA significantly reduces pain from venipuncture, and side effects are mild and transient.
在一项针对51名儿童的随机双盲研究中，对一种新型局部麻醉制剂——复方利多卡因乳膏（EMLA 5%乳膏，局部麻醉剂的共熔混合物）与安慰剂进行了比较。目的是测试EMLA是否能减轻静脉穿刺引起的疼痛，评估可能的不良反应，并确定其对静脉穿刺操作难易程度是否有影响。使用三级语言评分量表评估疼痛。EMLA缓解疼痛的效果明显优于安慰剂（p<0.001），并且在使用EMLA治疗后，静脉穿刺操作被认为更容易进行。未出现水肿，但在使用EMLA治疗后观察到少数局部发红和苍白的病例。然而，这些反应在临床上并不显著。结论是EMLA能显著减轻静脉穿刺引起的疼痛，且副作用轻微且短暂。
