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角膜移植术后加替沙星与泼尼松联合治疗后的角膜沉积物：1例罕见病例报告

Corneal Deposits Following Combined Gatifloxacin and Prednisolone Therapy Post-Keratoplasty: A Report of a Rare Case.

作者信息

Modgil Chaitanya, More Pranav, Lune Abhay, Mushtaq Iqra

机构信息

Ophthalmology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.

Ophthalmology (Cornea), Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.

出版信息

Cureus. 2024 Jul 10;16(7):e64283. doi: 10.7759/cureus.64283. eCollection 2024 Jul.

DOI:10.7759/cureus.64283
PMID:39131012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11315940/
Abstract

Corneal deposits associated with topical medications, particularly fluoroquinolones, are a recognized complication in ophthalmic practice. We present a case of a 66-year-old female with pseudophakic bullous keratopathy who developed corneal crystalline deposits following prolonged use of gatifloxacin and prednisolone eye drops post-penetrating keratoplasty. The patient presented with diminished vision and significant corneal opacity in the affected eye. Anterior segment examination and OCT imaging confirmed deposits extending from the epithelium to the anterior stroma. Management included corneal scrapping and transition to topical tobramycin and propylene glycol eye drops, resulting in the resolution of deposits and improvement in vision. This case underscores the importance of vigilant monitoring and judicious use of topical medications to mitigate adverse effects in high-risk ophthalmic patients undergoing corneal procedures.

摘要

与局部用药尤其是氟喹诺酮类药物相关的角膜沉积物是眼科实践中公认的一种并发症。我们报告一例66岁女性患者，患有假晶状体大泡性角膜病变，在穿透性角膜移植术后长期使用加替沙星和泼尼松龙滴眼液后出现角膜结晶沉积物。患者患眼视力下降且角膜明显混浊。前段检查和光学相干断层扫描（OCT）成像证实沉积物从上皮延伸至前基质。治疗措施包括角膜刮除术，并改用局部妥布霉素和丙二醇滴眼液，沉积物得以消退，视力有所改善。该病例强调了在接受角膜手术的高危眼科患者中，进行密切监测和合理使用局部药物以减轻不良反应的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/5c593a6c1d4c/cureus-0016-00000064283-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/5669b1add222/cureus-0016-00000064283-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/ee6d511c6df2/cureus-0016-00000064283-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/fafa2e51418d/cureus-0016-00000064283-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/5c593a6c1d4c/cureus-0016-00000064283-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/5669b1add222/cureus-0016-00000064283-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/ee6d511c6df2/cureus-0016-00000064283-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/fafa2e51418d/cureus-0016-00000064283-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e883/11315940/5c593a6c1d4c/cureus-0016-00000064283-i04.jpg

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本文引用的文献

1
Corneal deposits following topical moxifloxacin use.局部使用莫西沙星后的角膜沉积物。
Saudi J Ophthalmol. 2019 Apr-Jun;33(2):163-164. doi: 10.1016/j.sjopt.2018.04.006. Epub 2018 Apr 26.
2
Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series.穿透性角膜移植术后氟喹诺酮类药物在角膜的沉积：病例系列
Int Med Case Rep J. 2019 May 8;12:151-154. doi: 10.2147/IMCRJ.S198011. eCollection 2019.
3
Corneal crystalline deposits associated with topically applied gatifloxacin.与局部应用加替沙星相关的角膜晶体沉积物。
Cornea. 2014 Jun;33(6):638-9. doi: 10.1097/ICO.0000000000000101.
4
Ocular toxicity of fluoroquinolones.氟喹诺酮类药物的眼部毒性。
Clin Exp Ophthalmol. 2007 Aug;35(6):566-77. doi: 10.1111/j.1442-9071.2007.01552.x.
5
Corneal intrastromal gatifloxacin crystal deposits after penetrating keratoplasty.穿透性角膜移植术后角膜基质内加替沙星晶体沉积
Eye Contact Lens. 2004 Jul;30(3):169-72. doi: 10.1097/01.icl.0000133241.56713.2f.
6
Deposits in the superficial corneal stroma after combined topical corticosteroid and beta-blocking medication.局部联合使用皮质类固醇和β受体阻滞剂药物后角膜浅基质层的沉积物。
Eur J Ophthalmol. 1991 Oct-Dec;1(4):198-9. doi: 10.1177/112067219100100407.