用于治疗胃肠道无力的TOGA治疗性氧气。
TOGA Therapeutic Oxygen for Gastrointestinal Atony.
作者信息
Weiner Brian, Forsmark Chris, Khular Vikas, Bauman Alexandra, Sutchu Selina, Banerjee Debdeep, Westerveld Donevan, Zhang Wei, Jacobson Max, Grajo Joseph
机构信息
Division of Gastroenterology, Bruce W. Carter Veterans Administration Hospital, Miami, Florida.
Medicine/Gastroenterology, Florida Atlantic University Schmidt College of Medicine, Boca Raton, Florida.
出版信息
Gastro Hep Adv. 2024 Jan 3;3(3):402-409. doi: 10.1016/j.gastha.2023.12.013. eCollection 2024.
BACKGROUND AND AIMS
Ileus, mechanical bowel obstruction, and acute colonic pseudo-obstruction are characterized by distension of the intestines with accumulated bowel gas. Current treatments are not completely satisfactory.
METHODS
By manipulating the partial pressures of oxygen and nitrogen in the trapped air with a novel 6-hour treatment with 100% oxygen via nonrebreather mask, the bowel can be successfully decompressed, facilitating resolution of the underlying condition.
RESULTS
A positive clinical response was seen in 7/8 [87.5%] patients after therapeutic oxygen for gastrointestinal atony. Maximal lumen diameter decreased by an average of 1.14 ± 0.87 cm [16%].
CONCLUSION
In this first clinical report of therapeutic oxygen for gastrointestinal atony, the provision of 100% oxygen via nonrebreather mask is a useful therapy. It decreased the diameter of the intestinal lumen and enhanced resolution of ileus, acute colonic pseudo-obstruction, and bowel obstruction. This is a low-morbidity, low-cost treatment of gastrointestinal luminal distension.ClinicalTrials.gov Identifier NCT03386136.st.
背景与目的
肠梗阻、机械性肠梗阻和急性结肠假性梗阻的特征是肠道内积聚气体导致肠管扩张。目前的治疗方法并不完全令人满意。
方法
通过使用非重复呼吸面罩进行为期6小时的新型100%氧气治疗，调节被困气体中氧气和氮气的分压，可成功使肠道减压，促进潜在疾病的缓解。
结果
8例胃肠道无力患者接受治疗性氧气治疗后，7例（87.5%）出现了积极的临床反应。最大管腔直径平均减小1.14±0.87厘米（16%）。
结论
在这份关于治疗性氧气治疗胃肠道无力的首份临床报告中，通过非重复呼吸面罩提供100%氧气是一种有效的治疗方法。它减小了肠腔直径，促进了肠梗阻、急性结肠假性梗阻和肠道梗阻的缓解。这是一种治疗胃肠道管腔扩张的低发病率、低成本的治疗方法。ClinicalTrials.gov标识符：NCT03386136。
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