Rahayu Endang S, Yoga Wahyu K, Komalasari Husnita, Mariyatun Mariyatun, Yuda Wednes A, Manurung Nancy E P, Hasan Pratama N, Suharman Suharman, Pamungkaningtyas Fathyah H, Nurfiana Dina A, Pramesi Putrika C, Gatya Mifta, Therdtatha Phatthanaphong, Nakayama Jiro, Juffrie Mohammad, Djaafar Titiek F, Marwati Tri, Utami Tyas
Faculty of Agricultural Technology Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Center for Food and Nutrition Studies Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Int J Food Sci. 2024 Aug 3;2024:9493797. doi: 10.1155/2024/9493797. eCollection 2024.
The present study investigated the ingestion effect of chocolate probiotic containing Dad-13 in undernourished children. A 100-day observation was conducted on undernourished children in Lombok, who were divided into probiotic ( = 28) and placebo ( = 28) groups. Fecal sampling was performed on the 10 and 100 days and further analyzed for gut microbiota composition, short-chain fatty acid (SCFA), and fecal pH. A significant difference was found in the diversity index, fecal pH, and several microbiotas at the phylum and genus levels. At the phylum level, was significantly higher in the probiotic group, and a higher relative abundance (RA) of was found in the placebo group. At the genus level, significant differences were observed in some bacteria, such as and . Therefore, it can be concluded that the probiotic intervention in this study resulted in changes of gut microbiota diversity and fecal pH. Thai Clinical Trials Registry identifier: TCTR20220425001.
本研究调查了含Dad-13的巧克力益生菌对营养不良儿童的摄入效果。对龙目岛的营养不良儿童进行了为期100天的观察，这些儿童被分为益生菌组（n = 28）和安慰剂组（n = 28）。在第10天和第100天进行粪便采样，并进一步分析肠道微生物群组成、短链脂肪酸（SCFA）和粪便pH值。在多样性指数、粪便pH值以及门和属水平的几种微生物群方面发现了显著差异。在门水平上，益生菌组中的[具体菌门]显著更高，而安慰剂组中[另一种具体菌门]的相对丰度（RA）更高。在属水平上，在一些细菌（如[具体细菌属1]和[具体细菌属2]）中观察到显著差异。因此，可以得出结论，本研究中的益生菌干预导致了肠道微生物群多样性和粪便pH值的变化。泰国临床试验注册标识符：TCTR20220425001。
