Cartel J L, Gallais J J, Grosset J H
Acta Leprol. 1985 Oct-Dec;3(4):339-55.
From January 1980 to December 1984, 418 leprosy patients were treated in Guadeloupe with a daily multiple drug regimen using rifampin as an essential drug. The analysis of the data collected during this period of times gives the possibility of estimating the patient's approval, tolerance and attendance to this treatment. The approval is satisfactory in new cases of leprosy and in ancient cases relapsed under dapsone monotherapy but less in inactive ancient patients already treated with dapsone monotherapy. Attendance of the 418 patients to the multiple drug regimen is satisfactory too and similar to the attendance of patients treated with dapsone monotherapy in Guadeloupe and to the attendance of patients with monthly multiple drug regimen in another Caribbean country. Reactions did not occur with higher gravity or frequency than in patients under dapsone monotherapy. The high incidence of hepatitis (14%) due to the toxicity of protionamide in the combination rifampin-protionamide-dapsone make obligatory the monthly assessment of the liver functions in multibacillary patients treated with such a drug combination.
1980年1月至1984年12月期间，瓜德罗普岛的418名麻风病患者采用以利福平为基本药物的每日多药联合疗法进行治疗。对这一时期收集的数据进行分析，使得评估患者对该治疗的接受度、耐受性和依从性成为可能。在麻风病新发病例以及在单一氨苯砜治疗下复发的旧病例中，接受度令人满意，但在已接受单一氨苯砜治疗的静止期旧病例中接受度较低。418名患者对多药联合疗法的依从性也令人满意，与瓜德罗普岛接受单一氨苯砜治疗的患者的依从性以及另一个加勒比国家接受每月一次多药联合疗法的患者的依从性相似。与单一氨苯砜治疗的患者相比，不良反应的严重程度和发生频率并未更高。由于利福平 - 丙硫异烟胺 - 氨苯砜联合用药中丙硫异烟胺的毒性导致肝炎发病率较高（14%），因此对于接受这种药物联合治疗的多菌型患者，必须每月进行肝功能评估。
