School of Pharmaceutical Sciences, Zhengzhou University, 100 Science Road, Zhengzhou 450001, People's Republic of China.
Henan Key Laboratory of Nanomedicine for Targeting Diagnosis and Treatment, 100 Science Road, Zhengzhou 450001, People's Republic of China.
ACS Appl Mater Interfaces. 2024 Aug 21;16(33):43156-43170. doi: 10.1021/acsami.4c09536. Epub 2024 Aug 12.
Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in the biomedical field based on the advantages of internal porosity, customizable porosity, and facile surface modification. This review examines the utilization of MOFs in drug delivery systems, focusing on the research progress from the aspects of coloading drug systems, intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, and multifunctional living carriers. In addition, the current challenges the research faces are also discussed. The review aims to provide a reference for the further application of MOFs as advanced drug delivery systems.
金属-有机骨架（MOFs）是通过金属离子和有机配体的配位作用形成的复合结晶材料。MOFs 具有内部多孔性、可定制多孔性和易于表面修饰等优点，在生物医学领域引起了广泛关注。本综述考察了 MOFs 在药物传递系统中的应用，重点从共载药系统、智能响应载体、生物大分子稳定剂、自驱动微/纳米马达和多功能活体载体等方面介绍了研究进展。此外，还讨论了研究中面临的当前挑战。本综述旨在为 MOFs 作为先进药物传递系统的进一步应用提供参考。
