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Protein folding: From physics-chemical rules and cellular machineries of protein quality control to AI solutions.

作者信息

Shimanovich Ulyana, Hartl F Ulrich

机构信息

Department of Molecular Chemistry and Materials Science, Faculty of Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel.

Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

出版信息

Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2411135121. doi: 10.1073/pnas.2411135121. Epub 2024 Aug 12.

DOI:10.1073/pnas.2411135121
PMID:39133840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11348304/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4433/11348304/8c3dfec51dea/pnas.2411135121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4433/11348304/8c3dfec51dea/pnas.2411135121fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4433/11348304/8c3dfec51dea/pnas.2411135121fig01.jpg

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本文引用的文献

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Conservation of kinetic stability, but not the unfolding mechanism, between human transthyretin and a transthyretin-related enzyme.在人类转甲状腺素蛋白和一种转甲状腺素蛋白相关酶之间,动力学稳定性得以保持,但解折叠机制则不然。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315007121. doi: 10.1073/pnas.2315007121. Epub 2024 Aug 12.
2
Insights into the interaction between UGGT, the gatekeeper of folding in the ER, and its partner, the selenoprotein SEP15.深入了解内质网折叠“守门员”UGGT 与其伴侣硒蛋白 SEP15 之间的相互作用。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315009121. doi: 10.1073/pnas.2315009121. Epub 2024 Aug 12.
3
AlphaFold2-based prediction of the co-condensation propensity of proteins.
基于 AlphaFold2 的蛋白质共凝聚倾向预测。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315005121. doi: 10.1073/pnas.2315005121. Epub 2024 Aug 12.
4
Sound-mediated nucleation and growth of amyloid fibrils.声介导的淀粉样纤维的成核和生长。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315510121. doi: 10.1073/pnas.2315510121. Epub 2024 Aug 12.
5
Origins of Life: The Protein Folding Problem all over again?生命起源:蛋白质折叠问题再现?
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315000121. doi: 10.1073/pnas.2315000121. Epub 2024 Aug 12.
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Addressing epistasis in the design of protein function.解决蛋白质功能设计中的上位效应。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2314999121. doi: 10.1073/pnas.2314999121. Epub 2024 Aug 12.
7
AlphaFold two years on: Validation and impact.两年后的AlphaFold:验证与影响。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315002121. doi: 10.1073/pnas.2315002121. Epub 2024 Aug 12.
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Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways.α-突触核蛋白的 2 到 7 个残基通过依赖脂质和不依赖脂质的途径调节淀粉样形成。
Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2315006121. doi: 10.1073/pnas.2315006121. Epub 2024 Aug 12.
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