Department of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Cancer Institute of Jiangsu University, Zhenjiang, China.
Int Immunopharmacol. 2024 Oct 25;140:112888. doi: 10.1016/j.intimp.2024.112888. Epub 2024 Aug 11.
Pancreatic cancer is characterized by an extremely poor prognosis and presents significant treatment challenges. Liver metastasis is the leading cause of death in patients with pancreatic cancer. Recent studies have highlighted the significant impact of neutrophils on tumor occurrence and progression, as well as their crucial role in the pancreatic cancer tumor microenvironment. Neutrophil infiltration plays a critical role in the progression and prognosis of pancreatic cancer. Neutrophils contribute to pancreatic cancer liver metastasis through various mechanisms, including angiogenesis, immune suppression, immune evasion, and epithelial-mesenchymal transition (EMT). Therefore, targeting neutrophils holds promise as an important therapeutic strategy for inhibiting pancreatic cancer liver metastasis. This article provides a summary of research findings on the involvement of neutrophils in pancreatic cancer liver metastasis and analyzes their potential as therapeutic targets. This research may provide new insights for the treatment of pancreatic cancer and improve the prognosis of patients with this disease.
胰腺癌的预后极差，治疗极具挑战性。肝转移是导致胰腺癌患者死亡的主要原因。最近的研究强调了中性粒细胞对肿瘤发生和进展的重大影响，以及它们在胰腺癌肿瘤微环境中的关键作用。中性粒细胞浸润在胰腺癌的进展和预后中起着关键作用。中性粒细胞通过多种机制促进胰腺癌肝转移，包括血管生成、免疫抑制、免疫逃逸和上皮-间充质转化（EMT）。因此，靶向中性粒细胞有望成为抑制胰腺癌肝转移的重要治疗策略。本文总结了中性粒细胞参与胰腺癌肝转移的研究发现，并分析了它们作为治疗靶点的潜力。这项研究可能为胰腺癌的治疗提供新的思路，并改善该疾病患者的预后。
