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Targeting cardiac fibrosis with chimeric antigen receptor macrophages.

作者信息

Gao Zibei, Yan Lei, Meng Jufeng, Lu Zhengkai, Ge Kaixin, Jiang Zhen, Feng Teng, Wang Haopeng, Liu Chen, Tang Juan, Zhang Hui

机构信息

School of Life Science and Technology & Shanghai Clinical Research and Trial Center, ShanghaiTech University, Shanghai, China.

State Key Laboratory of Cardiovascular Disease and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Science and Technology, Tongji University, Shanghai, China.

出版信息

Cell Discov. 2024 Aug 13;10(1):86. doi: 10.1038/s41421-024-00718-4.

DOI:10.1038/s41421-024-00718-4
PMID:39134538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11319452/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd0/11319452/3e9d19096c35/41421_2024_718_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd0/11319452/3e9d19096c35/41421_2024_718_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd0/11319452/3e9d19096c35/41421_2024_718_Fig1_HTML.jpg

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本文引用的文献

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A second-generation M1-polarized CAR macrophage with antitumor efficacy.第二代 M1 极化的 CAR 巨噬细胞具有抗肿瘤疗效。
Nat Immunol. 2024 Jan;25(1):102-116. doi: 10.1038/s41590-023-01687-8. Epub 2023 Nov 27.
2
CAR T cells produced in vivo to treat cardiac injury.体内生成的 CAR T 细胞治疗心脏损伤。
Science. 2022 Jan 7;375(6576):91-96. doi: 10.1126/science.abm0594. Epub 2022 Jan 6.
3
Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation.肌成纤维细胞与纤维化：细胞分化的线粒体与代谢调控
Clin Transl Med. 2025 Apr;15(4):e70306. doi: 10.1002/ctm2.70306.
4
Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets.抗原呈递成纤维细胞：免疫调节中的新兴角色和治疗靶点。
Theranostics. 2025 Feb 18;15(8):3332-3344. doi: 10.7150/thno.104900. eCollection 2025.
5
Complex regulation of cardiac fibrosis: insights from immune cells and signaling pathways.心脏纤维化的复杂调控：来自免疫细胞和信号通路的见解
J Transl Med. 2025 Feb 28;23(1):242. doi: 10.1186/s12967-025-06260-5.
6
The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review.长链非编码RNA在心血管疾病中的作用：综述
Noncoding RNA Res. 2024 Dec 28;11:158-187. doi: 10.1016/j.ncrna.2024.12.009. eCollection 2025 Apr.
Circ Res. 2020 Jul 17;127(3):427-447. doi: 10.1161/CIRCRESAHA.120.316958. Epub 2020 Jul 16.
4
Targeting cardiac fibrosis with engineered T cells.靶向心肌纤维化的工程化 T 细胞。
Nature. 2019 Sep;573(7774):430-433. doi: 10.1038/s41586-019-1546-z. Epub 2019 Sep 11.
5
Genetic lineage tracing defines myofibroblast origin and function in the injured heart.遗传谱系追踪定义了心肌梗死后损伤心脏中肌成纤维细胞的起源和功能。
Nat Commun. 2016 Jul 22;7:12260. doi: 10.1038/ncomms12260.
6
Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice.靶向消融骨膜蛋白表达的激活成纤维细胞可预防小鼠心脏不良重构。
Circ Res. 2016 Jun 10;118(12):1906-17. doi: 10.1161/CIRCRESAHA.116.308643. Epub 2016 May 2.
7
Cardiac Fibrosis: The Fibroblast Awakens.心脏纤维化：成纤维细胞觉醒
Circ Res. 2016 Mar 18;118(6):1021-40. doi: 10.1161/CIRCRESAHA.115.306565.
8
Apoptotic cell recognition receptors and scavenger receptors.凋亡细胞识别受体与清道夫受体
Immunol Rev. 2016 Jan;269(1):44-59. doi: 10.1111/imr.12376.
9
Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction.成纤维细胞激活蛋白α表达鉴定心肌梗死后激活的成纤维细胞。
J Mol Cell Cardiol. 2015 Oct;87:194-203. doi: 10.1016/j.yjmcc.2015.08.016. Epub 2015 Aug 28.
10
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity.嵌合抗原受体 T 细胞靶向肿瘤基质中的成纤维细胞激活蛋白可抑制肿瘤生长并增强宿主免疫而无严重毒性。
Cancer Immunol Res. 2014 Feb;2(2):154-66. doi: 10.1158/2326-6066.CIR-13-0027. Epub 2013 Nov 12.