Department of Operation Room, Hospital of Stomatology, Jilin University, Changchun, China.
Department of Endodontics, Hospital of Stomatology, Jilin University, Changchun, China.
Stem Cell Rev Rep. 2024 Nov;20(8):2124-2137. doi: 10.1007/s12015-024-10769-5. Epub 2024 Aug 12.
Approximately half of the adult population is suffering from periodontal disease, and conventional periodontal treatment strategies can only slow the progression of the disease. As a kind of tissue engineering, periodontal regeneration brings hope for the treatment of periodontal disease. Low-intensity pulsed ultrasound (LIPUS) is a form of ultrasound with a frequency of 1-3 MHz and a much lower intensity (< 1W/cm) than traditional ultrasound energy and output. LIPUS has been adopted for a variety of therapeutic purposes due to its bioeffects such as thermal, mechanical, and cavitation effects, which induce intracellular biochemical effects and lead to tissue repair and regeneration ultimately. In this systematic review, we summarize the basic research of LIPUS in the treatment of periodontal disease in periodontal disease animal models and the influence of LIPUS on the biological behavior (including promoting osteogenic differentiation of stem cells and inhibiting inflammatory response) and potential mechanism of periodontal ligament stem cells (PDLSCs), hoping to provide new ideas for the treatment of periodontal disease. We believe that LIPUS can be used as an auxiliary strategy in the treatment of periodontal disease and play an exciting and positive role in periodontal regeneration.
约有一半的成年人患有牙周病，而传统的牙周病治疗策略只能减缓疾病的进展。作为一种组织工程，牙周再生为牙周病的治疗带来了希望。低强度脉冲超声（LIPUS）是一种频率为 1-3 MHz 的超声形式，其强度（<1 W/cm）比传统超声能量和输出低得多。由于其热、机械和空化效应等生物效应，LIPUS 已被用于多种治疗目的，这些生物效应会引起细胞内生化效应，最终导致组织修复和再生。在本系统评价中，我们总结了牙周病动物模型中 LIPUS 治疗牙周病的基础研究，以及 LIPUS 对牙周韧带干细胞（PDLSCs）的生物学行为（包括促进干细胞成骨分化和抑制炎症反应）和潜在机制的影响，希望为牙周病的治疗提供新的思路。我们相信，LIPUS 可以作为牙周病治疗的辅助策略，在牙周再生中发挥令人兴奋和积极的作用。
