Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China.
Department of Research and Development, Nanjing Geneseeq Technology Inc., Nanjing, China.
Front Public Health. 2022 Oct 20;10:1003013. doi: 10.3389/fpubh.2022.1003013. eCollection 2022.
eosinophilic meningitis (AEM) is a rare yet emerging disease caused by infection. Its atypical symptoms may delay the diagnosis and cause fatal outcomes, especially in the early stages of infection and among children.
Here we reported the use of metagenomic next-generation sequencing (mNGS) to facilitate the diagnosis and treatment of an 8-year-old boy with severe infection. The mNGS tests consistently identified the infection of prior to the detection by the immunologic method and confirmed it as AEM. Owing to the multidisciplinary team (MDT)-administrated treatments and close disease monitoring based on regular clinical tests and sequential mNGS tests, the patients eventually fully recovered from severe infectious conditions.
This case demonstrated the advantages of mNGS for early diagnosis of AEM in pediatric patients, highlighting its application for pan-pathogen detection, as well as disease monitoring for severe infection.
嗜酸性粒细胞性脑膜炎（AEM）是一种由寄生虫感染引起的罕见但正在出现的疾病。其非典型症状可能会延迟诊断并导致致命后果，尤其是在感染的早期阶段和儿童中。
在这里，我们报告了使用宏基因组下一代测序（mNGS）来促进诊断和治疗一名 8 岁男孩的严重寄生虫感染。mNGS 检测持续识别出寄生虫感染，早于免疫方法的检测，并证实为 AEM。由于多学科团队（MDT）管理的治疗以及基于常规临床检测和连续 mNGS 检测的密切疾病监测，患者最终从严重感染状况中完全康复。
本病例证明了 mNGS 对儿科患者 AEM 的早期诊断的优势，突出了其用于泛病原体检测以及严重寄生虫感染的疾病监测的应用。
