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胃肠道担子菌病的非典型表现及伏立康唑的罕见副作用:一例报告及文献综述

Atypical presentation for a gastrointestinal basidiobolomycosis and rare side effect of Voriconazole: A case report and literature review.

作者信息

Abulhamail Albraa S, Alsubaie Mohammed A, Bahawi Yara O

机构信息

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Department of Pediatrics, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia.

出版信息

Med Mycol Case Rep. 2025 Jul 17;49:100719. doi: 10.1016/j.mmcr.2025.100719. eCollection 2025 Sep.

DOI:10.1016/j.mmcr.2025.100719
PMID:40727657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12301767/
Abstract

Gastrointestinal basidiobolomycosis (GIB) is a rare fungal infection often misdiagnosed with other gastrointestinal disorders. We report a case of a 6-year-old boy from Saudi Arabia who presented with fever, abdominal pain, and weight loss, initially suspected to have inflammatory bowel disease. Despite antibiotics, symptoms persisted, leading to a GIB diagnosis with liver involvement. IV voriconazole improved his condition but caused visual hallucinations, managed by dose adjustments. This case underscores the need for early suspicion of GIB in endemic areas and highlights the importance of prompt diagnosis and a multidisciplinary approach to improve outcomes and reduce complications.

摘要

胃肠道蛙粪霉病(GIB)是一种罕见的真菌感染,常被误诊为其他胃肠道疾病。我们报告一例来自沙特阿拉伯的6岁男孩,他出现发热、腹痛和体重减轻,最初怀疑患有炎症性肠病。尽管使用了抗生素,症状仍持续存在,最终诊断为伴有肝脏受累的GIB。静脉注射伏立康唑改善了他的病情,但导致了视幻觉,通过调整剂量进行处理。该病例强调了在流行地区早期怀疑GIB的必要性,并突出了及时诊断和多学科方法对于改善预后和减少并发症的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/829412052871/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/637408b01e4f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/6fe81d40c182/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/523d396ebb02/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/3510f1153f23/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/829412052871/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/637408b01e4f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/6fe81d40c182/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/523d396ebb02/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/3510f1153f23/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4cb/12301767/829412052871/gr5.jpg

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本文引用的文献

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Navigating treatment for basidiobolomycosis: a qualitative review of 24 cases.探讨 basidiobolomycosis 的治疗方法:24 例病例的定性回顾。
BMC Infect Dis. 2024 Aug 12;24(1):816. doi: 10.1186/s12879-024-09664-8.
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Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia.小儿胃肠道蛙粪霉病:沙特阿拉伯吉赞省的一项回顾性研究
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Gastrointestinal basidiobolomycosis - A rare fungal infection: Challenging to diagnose yet treatable - Case report and literature review.
胃肠道蛙粪霉病——一种罕见的真菌感染:诊断具有挑战性但可治疗——病例报告及文献综述
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Pediatric intussusception due to basidiobolomycosis: a case report and literature review.小儿套叠性肠病:由巴西蘑菇病引起:病例报告和文献复习。
BMC Pediatr. 2022 Jul 20;22(1):427. doi: 10.1186/s12887-022-03495-9.
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A Case Report of Gastrointestinal Basidiobolomycosis Treated With Voriconazole: A Rare Emerging Entity.伏立康唑治疗胃肠道担子菌病1例报告:一种罕见的新出现疾病。
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