Gholami Zainab, Maracy Mohammad Reza, Paknahad Zamzam
School of Nutrition and Food Science, Students' Research Committee, Department of Clinical Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Heliyon. 2024 Jul 14;10(16):e34493. doi: 10.1016/j.heliyon.2024.e34493. eCollection 2024 Aug 30.
The MIND is a novel eating plan preserves cognitive function. Propolis is a resinous substance that has several biological and medicinal properties. This study examines the effect of the MIND diet and propolis supplementation on MetS indices among metabolic syndrome subjects. This RCT study, was conducted on adults with metabolic syndrome who were referred to the Hazrat Ali Health Center in Isfahan. 84 eligible subjects were divided into 3 groups. Including MIND diet + Propolis supplement, MIND diet + placebo, and control group. The data obtained from the subjects was analyzed in two descriptive and analytic levels. The Shapiro-Wilk test and examination of skewness were conducted to assess the normality of the distribution of quantitative variables. Quantitative variables were reported using either the mean (SD). SPSS Statistics software version 26 was used for statistical analysis of data. In this study the MIND + Propolis group compared to the control group after adjusting variables showed a significant decrease (p-value < 0.05) in weight, BMI, WC, SBP, DBP, and TG by 0.97 times (3%), 0.97 times (3%), 0.98 times (2%), 0.93 times (7%), 0.94 times (6%), and 0.75 times (25%), respectively; this significant change was also observed in FBS (p-value < 0.001) by 0.85 times (15%), and HDL-C (mg/dl) has shown a significant increase (p-value < 0.05) by 1.17 times (17%). MIND group compared to the control group after adjusting variables showed a significant decrease (p-value < 0.05) in BMI, WC, and SBP by 0.98 times (2%), 0.98 times (2%), and 0.95 times (5%), respectively; this significant change (p-value < 0.001) was also observed in DBP, FBS, and TG by 0.92 times (8%), 0.83 times (17%), and 0.71 times (29%), respectively; HDL-C has shown a significant increase (p-value < 0.001) by 1.21 times (21%), and weight has shown a non-significant decrease (p-value = 0.055) by 0.98 times (2%). This study indicated that the MIND diet + Propolis supplement and MIND diet compared to the control group can significantly decrease BMI, WC, SBP, DBP, FBS, TG, and weight (non-significant for the MIND group), and also increase HDL-C.
MIND饮食法是一种能够维持认知功能的新型饮食计划。蜂胶是一种具有多种生物学和药用特性的树脂状物质。本研究探讨了MIND饮食法和补充蜂胶对代谢综合征患者代谢综合征指标的影响。这项随机对照试验研究针对的是转诊至伊斯法罕哈扎特·阿里健康中心的成年代谢综合征患者。84名符合条件的受试者被分为3组，包括MIND饮食法+蜂胶补充剂组、MIND饮食法+安慰剂组和对照组。从受试者那里获得的数据在描述性和分析性两个层面进行了分析。进行了夏皮罗-威尔克检验和偏度检验以评估定量变量分布的正态性。定量变量采用均值（标准差）进行报告。使用SPSS Statistics软件26版对数据进行统计分析。在本研究中，调整变量后，MIND+蜂胶组与对照组相比，体重、体重指数、腰围、收缩压、舒张压和甘油三酯分别显著降低（p值<0.05）0.97倍（3%）、0.97倍（3%）、0.98倍（2%）、0.93倍（7%）、0.94倍（6%）和0.75倍（25%）；空腹血糖也有显著变化（p值<0.001），降低了0.85倍（15%），高密度脂蛋白胆固醇（mg/dl）显著升高（p值<0.05），升高了1.17倍（17%）。调整变量后，MIND组与对照组相比，体重指数、腰围和收缩压分别显著降低（p值<0.05）了0.98倍（2%）、0.98倍（2%）和0.95倍（5%）；舒张压、空腹血糖和甘油三酯也有显著变化（p值<0.001），分别降低了0.92倍（8%）、0.83倍（17%）和0.71倍（29%）；高密度脂蛋白胆固醇显著升高（p值<0.001），升高了1.21倍（21%），体重有非显著降低（p值=0.055），降低了0.98倍（2%）。本研究表明，与对照组相比，MIND饮食法+蜂胶补充剂组和MIND饮食法组可显著降低体重指数、腰围、收缩压、舒张压、空腹血糖、甘油三酯和体重（MIND组体重降低不显著），还可升高高密度脂蛋白胆固醇。
