Zhang Yubi, Deng Yu, Zhou Meng, Wu Bin, Zhou Jing
Department of Thyroid and Breast Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2024 Jul 29;14:1428274. doi: 10.3389/fonc.2024.1428274. eCollection 2024.
Intraglandular dissemination is an important pathological feature of thyroid cancer, yet the biological characteristics of this phenomenon remain relatively underexplored. This paper aims to provide a comprehensive overview of its biological behaviors, protein expressions, and identification methods. Several retrospective studies have found that thyroid cancers with intraglandular dissemination have higher rates of lymph node metastasis, capsule invasion, and vascular invasion, exhibiting more aggressive biological behavior. Immunohistochemistry results show abnormal expression of proteins such as FKBP5, CENPF, CX26, KIF11, PTK7, which are associated with poor prognosis in thyroid cancers with intraglandular dissemination, offering potential guidance for specific targeted therapy in the future. Moreover, adjunctive techniques including ultrasound, fine-needle aspiration, and genetic testing offer valuable support in accurately identifying these cases, facilitating moreproactive treatment and closer follow-up.
腺内播散是甲状腺癌的一个重要病理特征，然而这一现象的生物学特性仍未得到充分研究。本文旨在全面概述其生物学行为、蛋白表达及识别方法。多项回顾性研究发现，发生腺内播散的甲状腺癌有更高的淋巴结转移、包膜侵犯及血管侵犯发生率，表现出更具侵袭性的生物学行为。免疫组化结果显示FKBP5、CENPF、CX26、KIF11、PTK7等蛋白表达异常，这些蛋白与发生腺内播散的甲状腺癌预后不良相关，为未来的特异性靶向治疗提供了潜在指导。此外，包括超声、细针穿刺及基因检测在内的辅助技术在准确识别这些病例方面提供了有价值的支持，有助于更积极的治疗及更密切的随访。
