• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于场效应晶体管的生物传感器的最新进展：器件视角

Recent progress on field-effect transistor-based biosensors: device perspective.

作者信息

Smaani Billel, Nafa Fares, Benlatrech Mohamed Salah, Mahdi Ismahan, Akroum Hamza, Walid Azizi Mohamed, Harrar Khaled, Kanungo Sayan

机构信息

Abdelhafid Boussouf University Centre of Mila, Mila, Algeria.

University of Jijel, Automation Department, Jijel, Algeria.

出版信息

Beilstein J Nanotechnol. 2024 Aug 6;15:977-994. doi: 10.3762/bjnano.15.80. eCollection 2024.

DOI:10.3762/bjnano.15.80
PMID:39136041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11318611/
Abstract

Over the last few decades, field-effect transistor (FET)-based biosensors have demonstrated great potential across various industries, including medical, food, agriculture, environmental, and military sectors. These biosensors leverage the electrical properties of transistors to detect a wide range of biomolecules, such as proteins, DNA, and antibodies. This article presents a comprehensive review of advancements in the architectures of FET-based biosensors aiming to enhance device performance in terms of sensitivity, detection time, and selectivity. The review encompasses an overview of emerging FET-based biosensors and useful guidelines to reach the best device dimensions, favorable design, and realization of FET-based biosensors. Consequently, it furnishes researchers with a detailed perspective on design considerations and applications for future generations of FET-based biosensors. Finally, this article proposes intriguing avenues for further research on the topology of FET-based biosensors.

摘要

在过去几十年中，基于场效应晶体管（FET）的生物传感器在包括医疗、食品、农业、环境和军事等各个行业都展现出了巨大潜力。这些生物传感器利用晶体管的电学特性来检测多种生物分子，如蛋白质、DNA和抗体。本文全面综述了基于FET的生物传感器架构的进展，旨在从灵敏度、检测时间和选择性等方面提高器件性能。该综述涵盖了新兴的基于FET的生物传感器概述以及实现最佳器件尺寸、良好设计和基于FET的生物传感器的有用指导方针。因此，它为研究人员提供了关于下一代基于FET的生物传感器的设计考虑因素和应用的详细视角。最后，本文提出了关于基于FET的生物传感器拓扑结构进一步研究的有趣途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1dd5a9fdaf4a/Beilstein_J_Nanotechnol-15-977-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/61e05450105b/Beilstein_J_Nanotechnol-15-977-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/cf8fc0d92c03/Beilstein_J_Nanotechnol-15-977-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/0010ab024d38/Beilstein_J_Nanotechnol-15-977-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/91c3bb8855d9/Beilstein_J_Nanotechnol-15-977-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1312677ce6cc/Beilstein_J_Nanotechnol-15-977-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1c2796a6735c/Beilstein_J_Nanotechnol-15-977-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/6e74994b6166/Beilstein_J_Nanotechnol-15-977-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/62a5406fa948/Beilstein_J_Nanotechnol-15-977-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/6d0ccc2d6730/Beilstein_J_Nanotechnol-15-977-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/d7e9db27208f/Beilstein_J_Nanotechnol-15-977-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/2c52537ad635/Beilstein_J_Nanotechnol-15-977-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/f1dd5e2a4618/Beilstein_J_Nanotechnol-15-977-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/e51bf605d0ba/Beilstein_J_Nanotechnol-15-977-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/69289aaba6ee/Beilstein_J_Nanotechnol-15-977-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/d9763f1ae0aa/Beilstein_J_Nanotechnol-15-977-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/801c1fb6a360/Beilstein_J_Nanotechnol-15-977-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/9def018279fe/Beilstein_J_Nanotechnol-15-977-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1de4d7d590b4/Beilstein_J_Nanotechnol-15-977-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/a62b72d0fd2e/Beilstein_J_Nanotechnol-15-977-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/21dac8f27130/Beilstein_J_Nanotechnol-15-977-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1dd5a9fdaf4a/Beilstein_J_Nanotechnol-15-977-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/61e05450105b/Beilstein_J_Nanotechnol-15-977-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/cf8fc0d92c03/Beilstein_J_Nanotechnol-15-977-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/0010ab024d38/Beilstein_J_Nanotechnol-15-977-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/91c3bb8855d9/Beilstein_J_Nanotechnol-15-977-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1312677ce6cc/Beilstein_J_Nanotechnol-15-977-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1c2796a6735c/Beilstein_J_Nanotechnol-15-977-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/6e74994b6166/Beilstein_J_Nanotechnol-15-977-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/62a5406fa948/Beilstein_J_Nanotechnol-15-977-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/6d0ccc2d6730/Beilstein_J_Nanotechnol-15-977-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/d7e9db27208f/Beilstein_J_Nanotechnol-15-977-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/2c52537ad635/Beilstein_J_Nanotechnol-15-977-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/f1dd5e2a4618/Beilstein_J_Nanotechnol-15-977-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/e51bf605d0ba/Beilstein_J_Nanotechnol-15-977-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/69289aaba6ee/Beilstein_J_Nanotechnol-15-977-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/d9763f1ae0aa/Beilstein_J_Nanotechnol-15-977-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/801c1fb6a360/Beilstein_J_Nanotechnol-15-977-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/9def018279fe/Beilstein_J_Nanotechnol-15-977-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1de4d7d590b4/Beilstein_J_Nanotechnol-15-977-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/a62b72d0fd2e/Beilstein_J_Nanotechnol-15-977-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/21dac8f27130/Beilstein_J_Nanotechnol-15-977-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/1dd5a9fdaf4a/Beilstein_J_Nanotechnol-15-977-g022.jpg

相似文献

1
Recent progress on field-effect transistor-based biosensors: device perspective.基于场效应晶体管的生物传感器的最新进展：器件视角
Beilstein J Nanotechnol. 2024 Aug 6;15:977-994. doi: 10.3762/bjnano.15.80. eCollection 2024.
2
Recent advances in the detection of pathogenic microorganisms and toxins based on field-effect transistor biosensors.基于场效应晶体管生物传感器的致病微生物和毒素检测的最新进展。
Crit Rev Food Sci Nutr. 2024;64(25):9161-9190. doi: 10.1080/10408398.2023.2208677. Epub 2023 May 12.
3
Interface-Engineered Field-Effect Transistor Electronic Devices for Biosensing.用于生物传感的界面工程场效应晶体管电子器件
Adv Mater. 2023 Dec 4:e2306252. doi: 10.1002/adma.202306252.
4
Toward the Commercialization of Carbon Nanotube Field Effect Transistor Biosensors.迈向碳纳米管场效应晶体管生物传感器的商业化。
Biosensors (Basel). 2023 Feb 27;13(3):326. doi: 10.3390/bios13030326.
5
Nano-FET-enabled biosensors: Materials perspective and recent advances in North America.基于纳米场效应晶体管的生物传感器：材料视角与北美地区的最新进展
Biosens Bioelectron. 2021 Mar 15;176:112941. doi: 10.1016/j.bios.2020.112941. Epub 2020 Dec 30.
6
Field effect transistor based wearable biosensors for healthcare monitoring.基于场效应晶体管的可穿戴生物传感器用于医疗保健监测。
J Nanobiotechnology. 2023 Nov 7;21(1):411. doi: 10.1186/s12951-023-02153-1.
7
Graphene transistor-based biosensors for rapid detection of SARS-CoV-2.基于石墨烯晶体管的生物传感器，用于快速检测 SARS-CoV-2。
Bioelectrochemistry. 2024 Apr;156:108623. doi: 10.1016/j.bioelechem.2023.108623. Epub 2023 Dec 2.
8
Investigating on sensing mechanism of MoS-FET biosensors in response to proteins.研究 MoS-FET 生物传感器对蛋白质响应的传感机制。
Nanotechnology. 2023 Aug 14;34(43). doi: 10.1088/1361-6528/aceb6a.
9
Field-Effect Transistor Biosensors for Biomedical Applications: Recent Advances and Future Prospects.场效应晶体管生物传感器在生物医学中的应用：最新进展和未来展望。
Sensors (Basel). 2019 Sep 28;19(19):4214. doi: 10.3390/s19194214.
10
Aptamer-functionalized field-effect transistor biosensors for disease diagnosis and environmental monitoring.用于疾病诊断和环境监测的适体功能化场效应晶体管生物传感器。
Exploration (Beijing). 2023 May 11;3(3):20210027. doi: 10.1002/EXP.20210027. eCollection 2023 Jun.

引用本文的文献

1
Biological Sensing Using Vertical MoS-Graphene Heterostructure-Based Field-Effect Transistor Biosensors.基于垂直MoS-石墨烯异质结构场效应晶体管生物传感器的生物传感
Biosensors (Basel). 2025 Jun 10;15(6):373. doi: 10.3390/bios15060373.

本文引用的文献

1
Biomarkers and biosensors for early cancer diagnosis, monitoring and prognosis.用于早期癌症诊断、监测和预后的生物标志物与生物传感器。
Pathol Res Pract. 2023 Oct;250:154812. doi: 10.1016/j.prp.2023.154812. Epub 2023 Sep 9.
2
Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study.栅极工程异质结构隧道场效应晶体管作为无标记生物传感器的研究：一项综合研究。
Appl Phys A Mater Sci Process. 2023;129(2):94. doi: 10.1007/s00339-023-06393-8. Epub 2023 Jan 10.
3
A detailed investigation of dielectric-modulated dual-gate TMD FET based label-free biosensor via analytical modelling.
通过解析建模对基于介质调制双栅 TMD FET 的无标记生物传感器进行详细研究。
Sci Rep. 2022 Dec 7;12(1):21115. doi: 10.1038/s41598-022-24677-6.
4
Advancement and Challenges of Biosensing Using Field Effect Transistors.利用场效应晶体管进行生物传感的进展与挑战。
Biosensors (Basel). 2022 Aug 17;12(8):647. doi: 10.3390/bios12080647.
5
Dielectrically Modulated III-V Compound Semiconductor Based Pocket Doped Tunnel FET for Label Free Biosensing Applications.用于无标记生物传感应用的基于介电调制III-V族化合物半导体的口袋掺杂隧道场效应晶体管。
IEEE Trans Nanobioscience. 2023 Jan;22(1):192-198. doi: 10.1109/TNB.2022.3178763. Epub 2022 Dec 29.
6
Performance Analysis of the Dielectrically Modulated Junction-Less Nanotube Field Effect Transistor for Biomolecule Detection.用于生物分子检测的介电调制无结纳米管场效应晶体管的性能分析
IEEE Trans Nanobioscience. 2023 Jan;22(1):174-181. doi: 10.1109/TNB.2022.3172702. Epub 2022 Dec 29.
7
Nanomaterial-Based Biosensors using Field-Effect Transistors: A Review.基于场效应晶体管的纳米材料生物传感器：综述
J Electron Mater. 2022;51(5):1950-1973. doi: 10.1007/s11664-022-09492-z. Epub 2022 Feb 26.
8
SERS-based lateral flow immunoassay for sensitive and simultaneous detection of anti-SARS-CoV-2 IgM and IgG antibodies by using gap-enhanced Raman nanotags.基于表面增强拉曼散射的侧向流动免疫分析法，通过使用间隙增强拉曼纳米标签灵敏且同时检测抗SARS-CoV-2 IgM和IgG抗体。
Sens Actuators B Chem. 2021 Dec 1;348:130706. doi: 10.1016/j.snb.2021.130706. Epub 2021 Sep 3.
9
Advances in Biosensors for Continuous Glucose Monitoring Towards Wearables.面向可穿戴设备的连续血糖监测生物传感器的进展
Front Bioeng Biotechnol. 2021 Aug 19;9:733810. doi: 10.3389/fbioe.2021.733810. eCollection 2021.
10
Global public health security and justice for vaccines and therapeutics in the COVID-19 pandemic.全球公共卫生安全与新冠疫情中疫苗和治疗方法的公平分配
EClinicalMedicine. 2021 Sep;39:101053. doi: 10.1016/j.eclinm.2021.101053. Epub 2021 Aug 3.