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基于场效应晶体管的生物传感器的最新进展:器件视角

Recent progress on field-effect transistor-based biosensors: device perspective.

作者信息

Smaani Billel, Nafa Fares, Benlatrech Mohamed Salah, Mahdi Ismahan, Akroum Hamza, Walid Azizi Mohamed, Harrar Khaled, Kanungo Sayan

机构信息

Abdelhafid Boussouf University Centre of Mila, Mila, Algeria.

University of Jijel, Automation Department, Jijel, Algeria.

出版信息

Beilstein J Nanotechnol. 2024 Aug 6;15:977-994. doi: 10.3762/bjnano.15.80. eCollection 2024.

Abstract

Over the last few decades, field-effect transistor (FET)-based biosensors have demonstrated great potential across various industries, including medical, food, agriculture, environmental, and military sectors. These biosensors leverage the electrical properties of transistors to detect a wide range of biomolecules, such as proteins, DNA, and antibodies. This article presents a comprehensive review of advancements in the architectures of FET-based biosensors aiming to enhance device performance in terms of sensitivity, detection time, and selectivity. The review encompasses an overview of emerging FET-based biosensors and useful guidelines to reach the best device dimensions, favorable design, and realization of FET-based biosensors. Consequently, it furnishes researchers with a detailed perspective on design considerations and applications for future generations of FET-based biosensors. Finally, this article proposes intriguing avenues for further research on the topology of FET-based biosensors.

摘要

在过去几十年中,基于场效应晶体管(FET)的生物传感器在包括医疗、食品、农业、环境和军事等各个行业都展现出了巨大潜力。这些生物传感器利用晶体管的电学特性来检测多种生物分子,如蛋白质、DNA和抗体。本文全面综述了基于FET的生物传感器架构的进展,旨在从灵敏度、检测时间和选择性等方面提高器件性能。该综述涵盖了新兴的基于FET的生物传感器概述以及实现最佳器件尺寸、良好设计和基于FET的生物传感器的有用指导方针。因此,它为研究人员提供了关于下一代基于FET的生物传感器的设计考虑因素和应用的详细视角。最后,本文提出了关于基于FET的生物传感器拓扑结构进一步研究的有趣途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b4d/11318611/61e05450105b/Beilstein_J_Nanotechnol-15-977-g002.jpg

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