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多功能纳米杂化材料，集声动力、光动力和光热治疗于一体。

All-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies.

机构信息

Nanotechnology Engineering Department, Faculty of Engineering, Sivas Cumhuriyet University, Sivas 58140, Türkiye.

Biochemistry Department, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas 58140, Türkiye.

出版信息

ACS Appl Mater Interfaces. 2024 Aug 21;16(33):43387-43399. doi: 10.1021/acsami.4c09715. Epub 2024 Aug 13.

DOI:10.1021/acsami.4c09715
PMID:39136145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11345719/
Abstract

A wide variety of methods are being developed to ultimately defeat cancer; while some of these strategies have shown highly positive results, there are serious obstacles to overcome to completely eradicate this disease. So, it is crucial to construct multifunctional nanostructures possessing intelligent capabilities that can be utilized to treat cancer. A possible strategy for producing these multifunctional nanostructures is to combine various cancer treatment techniques. Based on this point of view, we successfully synthesized multifunctional HCuS@CuS@Au-P(NIPAM--AAm)-PpIX nanohybrids. The peculiarities of these thermosensitive polymer-modified and protoporphyrin IX (PpIX)-loaded hollow nanohybrids are that they combine photodynamic therapy (PDT), sonodynamic therapy (SDT), and photothermal therapy (PTT) with an intelligent design. As an all-in-one nanohybrids, HCuS@CuS@Au-P(NIPAM--AAm)-PpIX nanohybrids were employed in the SDT-PDT-PTT combination therapy, which proved to have a synergistic therapeutic effect for in vitro tumor treatments against breast tumors.

摘要

正在开发各种各样的方法来最终战胜癌症; 虽然其中一些策略已经显示出非常积极的结果，但要彻底根除这种疾病还存在严重的障碍。因此，构建具有智能功能的多功能纳米结构来治疗癌症至关重要。产生这些多功能纳米结构的一种可能策略是结合各种癌症治疗技术。基于这一观点，我们成功合成了多功能 HCuS@CuS@Au-P(NIPAM--AAm)-PpIX 纳米杂化物。这些热敏聚合物修饰和原卟啉 IX（PpIX）负载的空心纳米杂化物的特点是，它们将光动力疗法（PDT）、声动力疗法（SDT）和光热疗法（PTT）与智能设计相结合。作为一种一体化的纳米杂化物，HCuS@CuS@Au-P(NIPAM--AAm)-PpIX 纳米杂化物被用于 SDT-PDT-PTT 联合治疗，在体外针对乳腺癌的肿瘤治疗中证明具有协同治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/11345719/c0eb14aa721f/am4c09715_0013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/11345719/3480f00302a5/am4c09715_0004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/11345719/bc265cea9af6/am4c09715_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/11345719/6dfff704ff96/am4c09715_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/11345719/39518d9270da/am4c09715_0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/11345719/c0eb14aa721f/am4c09715_0013.jpg

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